專題研究室

婦女癌症防治中心

主持人:朱堂元/Tang-Yuan Chu

聯絡資訊: TEL 03-856-18235#15610
E-mail:hidrchu@gmail.com                                                                                              

 

 

 

主持人簡介:

Professor Chu received his MD degree from National Defense Medical Center of Taiwan and PhD degree from Cornell University Medical Center. He was trained in Obstetrics and Gynecology and Gynecologic Oncology in Tri-Service General Hospital, Taiwan. 

In 2005, he was appointed to Tzu Chi Medical Center, Hualien, Taiwan, acting as chiefs of Department of Obstetrics and Gynecology, Department of Research and director of the Center for Prevention and Therapy of Gynecological Centers. 

He was the director of Graduate Institute of Medical Sciences of National Defense Medical Center, and the founder and director of Institute of Clinical Medicine and Institute of Medical Sciences in Tzu Chi University, Taiwan .

Professor Chu’s research focuses on the developmental mechanism of cervical cancer and the ovarian high-grade serous carcinoma (HGSC) and the clinical applications. Special effort was paid on the role of stromal sex-hormone receptors in the development of cervical cancer, and the initiation and promotion of HGSC originating in the fallopian tube epithelium. His research team has recently discovered multiple carcinogens and mechanisms relating to ovulation, responsible for the mutagenesis, mitogenesis and transformation of fallopian tube epithelium in the context of p53 loss. With the in-vitro and in-vivo study systems as well as clinical cohorts and tissue banking, his team is also developing drugs for chemoprevention and biomarkers for early detection of these two cancers.

 

現職:花蓮慈濟醫院婦產部主任
學歷:美國康乃爾大學醫學院 細胞生物及遺傳學博士
研究興趣/研究主題/研究方向/專長:婦科腫瘤、婦科感染、婦癌篩檢、抹片異常之診斷、腹腔鏡手術、遺傳諮詢
研究領域:癌症遺傳與表觀遺傳癌症與幹細胞發育人類乳突病毒與子宮頸癌、卵巢癌         

 

近期著作發表:

  1. Chen YC, Huang RL, Huang YK, Laio YP, Su PH, Wang HC, Chang CC, Lin YW, Yu MH, Chu TY, Lai HC. Methylomics analysis identifies epigenetically silenced genes and implies an activation of β-catenin signaling in cervical cancer. Int J Cancer. 2014 Jul 1;135(1):117-27.(SCI)
  2. Ding DC, Chu TY, Hsu YH. Remission of anti-epiligrin cicatricial pemphigoid after excision of cervical adenocarcinoma. Cutan Pathol. 2014 Aug;41(8):692-3. doi: 10.1111/cup.12348. Epub 2014 Apr 26. No abstract available. (SCI)
  3. Chu TY*, Yang JT, Huang TH, Liu HW. Crosstalk with cancer-associated fibroblasts increases the growth and radiation survival of cervical cancer cells. Radiat Res. 2014 May;181(5):540-7. doi: 10.1667/RR13583.1. Epub 2014 May 1. (SCI)
  4. Lai HC, Ou YC, Chen TC, Huang HJ, Cheng YM, Chen CH, Chu TY, Hsu ST, Liu CB, Hung YC, Wen KC, Yu MH, Wang KL. PAX1/SOX1 DNA methylation and cervical neoplasia detection: a Taiwanese Gynecologic Oncology Group (TGOG) study. Cancer Med.  2014 Aug;3(4):1062-74.
  5. Ding DC, Wu KC, Chou HL, Hung WT, Liu HW, Chu TY. Human infra-patellar fat pad-derived stromal cells have more potent differentiation capacity than other mesenchymal cells and can be enhanced by hyaluronan. Cell Transplant. 2015;24(7):1221-32. doi: 10.3727/096368914X681937. Epub 2014 May 21. (SCI)
  6. Zhang C, Park JS, Grce M, Hibbitts S, Palefsky JM, Konno R, Smith-McCune KK, Giovannelli L, Chu TY, Picconi MA, Piña-Sánchez P, Settheetham-Ishida W, Coutlée F, De Marco F, Woo YL, Ho WC, Wong MC, Chirenje MZ, Magure T, Moscicki AB, Sabol I, Fiander AN, Chen Z, Chan MC, Cheung TH, Burk RD, Chan PK. Geographical Distribution and Risk Association of Human Papillomavirus Genotype 52-Variant Lineages. J Infect Dis. 2014 Nov 15;210(10):1600-4. doi: 10.1093/infdis/jiu310. Epub 2014 May 30. (SCI)
  7. Ding DC, Chu TY, Hsu YH. Large-cell neuro-endocrine carcinoma associated with borderline mucinous tumor of the ovary. Taiwan J Obstet Gynecol. 2014 Jun;53(2):270-2. doi: 10.1016/j.tjog.2013.04.040. No abstract available. (SCI)
  8. Su CC, Tseng KC, Lin MN, Hsieh TC, Chu TY*. High seroprevalence of human herpesvirus type 8 in patients with hepatocellular carcinoma. Eur J Clin Microbiol Infect Dis. 2015 Jan;34(1):55-62. doi: 10.1007/s10096-014-2206-8. Epub 2014 Jul 20. (SCI)
  9. Su CC, Lai CL, Tsao SM, Lin MN, Chu TY*. High seroprevalence of human herpesvirus type 8 infection in males with advanced lung carcinoma. Med Microbiol Immunol. 2015 Apr;204(2):177-83. doi: 10.1007/s00430-014-0352-3. Epub 2014 Aug 15.
  10. Lin H, Chen TC, Chang TC, Cheng YM, Chen CH, Chu TY, Hsu ST, Liu CB, Yeh LS, Wen KC, Huang CY, Yu MH. Methylated ZNF582 gene as a marker for triage of women with Pap smear reporting low-grade squamous intraepithelial lesions - A Taiwanese Gynecologic Oncology Group (TGOG) study. Gynecol Oncol. 2014 Oct;135(1):64-8. doi: 10.1016/j.ygyno.2014.08.012. Epub 2014 Aug 16. (SCI)

完整著作連結請點此

榮譽事項/學術獎勵:

1.         2016慈濟醫院研究卓越獎

2.         2014慈濟醫院優秀研究論文獎「資深人員組」第二名

3.         2010年國防醫學院傑出校友獎

4.         2009第十四屆台灣癌症聯合學術年會優秀壁報論文獎(一項)

5.         2008慈濟醫院優秀臨床研究論文獎「資深人員組」第一名

6.     2008第十三屆台灣癌症聯合學術年會優秀壁報論文獎(三項)2007第十二屆台灣癌症聯合學術年會優秀壁報論文獎(三項)

 

執行計畫(包含產學合作計畫)

補助/委託機構

計畫名稱

起迄日期

慈濟醫院跨院區計畫

排卵與環境因子對輸卵管繖部癌化之研究

102.01.01-104.12.31.

國科會性別科技

雌激素與子宮頸癌等女性賀爾蒙依賴性癌症發生的關係:健康資料串聯研究與臨床前期研究

102.8.1-103.7.31

慈濟醫院

以低毒性 Tamoxifen 作為復發或治療無效子宮頸癌搶救治療之臨床試驗

103.01.01-104.12.31

科技部

子宮頸基質雌激素受體在子宮頸癌化扮演的角色

103/08/01 105/07/31

生技醫藥國家型臨床試驗計畫

TamoxifenLetrozole在復發或持續性子宮頸鱗狀上皮癌之療效及新生物標記:多中心、隨機分配二期臨床試驗

103/12/01 105/5/31

慈濟醫療志業跨院校合作研究計畫

探討黃體素及選擇性黃體素受體調節劑(SPRM)對不同癌化程度的輸卵管分泌細胞之治療效果

104.08.01~107.07.31

慈濟醫院

氧化血紅素在排卵 ROS 誘發輸卵管上皮癌化所扮演的角色

105/01/01~105/12/31

科技部

高分化級別漿液性卵巢癌自輸卵管上皮癌化之研究:破解癌化過程之基因變化

105/08/01 107/07/31

慈濟醫院

黃體素受體在輸卵管上皮癌化的角色及成為治療目標的可行性研究

106/01/01~108/12/31

科技部

建構排卵誘發輸卵管癌化的之基因轉殖小鼠模式:高級別漿液性癌致癌機制與化學預 防之實證研究

107/08/01 110/07/31

慈濟醫療志業任務導向之跨院校合作研究計畫

以排卵濾泡液之致癌因子作為排卵致癌風險之生物標記研究

108.01.01~108.12.31

 

相關學會會員資格:

  1. 中華民國婦癌醫學會
  2. 台灣婦產科醫學會
  3. 台灣婦科醫學會
  4. 台灣婦癌醫學會

 

國內外學術期刊與研究審查委員:

  1. 國家衛生研究院婦癌臨床指引編撰專家
  2. 科技部「婦幼醫學」學門複審委員

近年重要會議邀請演講:

  • 2016台灣癌症聯合學術年會 
  • 2016第三屆湖南省婦科腫瘤國際論壇
  • 2015 Biennial conference of Asia Oceania Research Organisation on Genital Infection and Neoplasia(AOGIN)
  • 2014 The 6th Biennial conference of Asia Oceania Research Organisation on Genital Infection and Neoplasia(AOGIN)