慈濟醫院解剖病理部分子病理科主任

慈濟醫院解剖病理部主治醫師

慈濟醫療財團法人創新研發中心 副研發長

• 榮獲2023年花蓮慈院績優技轉獎
• 榮獲2023年國家新創獎之國家新創精進獎：HK-001-Wafer對抗人類惡性腦膠質瘤(GBM)
• 榮獲2022年國家新創獎之臨床新創獎：Cerebraca wafer治療經標準治療無效復發性惡性腦瘤
• 榮獲2021年國家新創獎之學研新創獎：定點緩釋給藥-開發治療胰臟癌新藥EF-009
• 榮獲2021年國家新創獎之精進續獎：HK-001-Wafer對抗人類惡性腦膠質瘤(GBM)
• 榮獲2021年國家新創獎之精進續獎：HK-001用於治療肌萎縮側索硬化(ALS)之開發計畫
• 榮獲2020年國家新創獎之學研新創獎：靶向Sox2的小分子LF-001應用於肺纖維化的治療
• 榮獲2019年三項國家新創獎：漸凍症、惡性腦瘤新藥以及癌症免疫療法
• 獲表揚為2018年美國國家發明家學會(National Academy of Inventors，NAI)新科院士
• 榮獲2017年以漸凍症新藥開發和iPS神經分化技術兩項國家新創獎

• 國防醫學院 醫學系
• 美國杜克大學 病理學博士
• 三軍總醫院外科病理科 主任
• 三軍總醫院病理部 主治醫師
• 三軍總醫院急診部 主治醫師
• 花蓮慈濟醫院急診部 主治醫師
• 花蓮慈濟醫院病理部 主治醫師
• 中國醫藥大學附設醫院病理部 主任
• 中國醫藥大學附設醫院病理部 主治醫師

1. Chen-Tran Hsu, Chi-Chou Chiu, Pao-Yuan Hsiao, Chih-Yu Lin, Sychyi Cheng, Yao-Cheng Lin, Yu-Liang Yang, Fu-Hui Wu, Horng-Jyh Harn, Shinn-Zong Lin, Choun-Sea Lin. Transgene-free CRISPR/Cas9-mediated gene editing through protoplast-to-plant regeneration enhances active compounds in Salvia miltiorrhiza. Plant Biotechnology Journal, Jan 2024. （本人為通訊作者）
2. Tsung-Yun Wu, Chun-Chiang Huang, Hsieh-Chih Tsai, Tzu-Kai Lin, Pei-Yu Chen, Haile Fentahun Darge, Zhen-Xiang Hong, Horng-Jyh Harn, Shinn-Zong Lin, Juin-Yih Lai, Yu-Shuan Chen. Mucin-mediated mucosal retention via end-terminal modified Pluronic F127-based hydrogel to increase drug accumulation in the lungs. Biomaterials Advances, Jan 2024.
3. Yu-Shuan Chen, Zhen-Xiang Hong, Yi-Tung Lin, En-Ci Tsao, Pei-Yu Chen, Ching-Ann Liu, Horng-Jyh Harn, Tzyy-Wen Chiou, Shinn-Zong Lin. Efficiency of PGK1 proteins delivered to the brain via a liposomal system through intranasal route administration for the treatment of spinocerebellar ataxia type 3. Drug Delivery and Translational Research, Dec 2023.
4. Yu-Shuan Chen, Horng-Jyh Harn, Zhen-Xiang Hong, Yi-Chen Huang, Yi-Tung Lin, Hui-Xuan Zheng, Pei-Yu Chen, Hsueh-Hui Yang, Peir-Rong Chen, Hsieh-Chih Tsai, Shinn-Zong Lin, Tsung-Jung Ho, Tzyy-Wen Chiou. Preconditioning of exosomes derived from human olfactory ensheathing cells improved motor coordination and balance in an SCA3/MJD mouse model: A new therapeutic approach. European Journal of Pharmaceutical Sciences 191:106608, Nov 2023.
5. Hsiao-Chien Ting, Hong-Lin Su, Mei-Fang Chen, Horng-Jyh Harn, Shinn-Zong Lin, Tzyy-Wen Chiou, Chia-Yu Chang. Robust Generation of Ready-to-Use Cryopreserved Motor Neurons from Human Pluripotent Stem Cells for Disease Modeling. International Journal of Molecular Sciences 23(21):13462, Nov 2022.
6. Shih-Fang Wu, Chih-Yao Lin, Rong-Kung Tsai, Yao-Tseng Wen, Feng-Huei Lin, Chia-Yu Chang, Ching-I Shen, Shinn-Zong Lin, Horng-Jyh Harn, Tzyy-Wen Chiou, Chin-San Liu, Yan-Ting Chen, Hong-Lin Su. Mitochondrial Transplantation Moderately Ameliorates Retinal Degeneration in Royal College of Surgeons Rats. Biomedicines 10(11):2883, Nov 2022.
7. Wei Wuli, Shinn-Zong Lin, Shee-Ping Chen, Bakhos A. Tannous, Wen-Sheng Huang, Peng Yeong Woon, Yang-Chang Wu, Hsueh-Hui Yang, Yi-Cheng Chen, Renata L. Fleming, Jack T. Rogers, Catherine M. Cahill, Tsung-Jung Ho, Tzyy-Wen Chiou, Horng-Jyh Harn. Targeting PSEN1 by lnc-CYP3A43-2/miR-29b-2-5p to Reduce β Amyloid Plaque Formation and Improve Cognition Function. International Journal of Molecular Sciences 23(18):10554, Sep 2022. （本人為通訊作者）
8. Ching-Ann Liu, Horng-Jyh Harn, Kuan-Pin Chen, Jui-Hao Lee, Shinn-Zong Lin, Tsung-Lang Chiu. Targeting the Axl and mTOR Pathway Synergizes Immunotherapy and Chemotherapy to Butylidenephthalide in a Recurrent GBM. Journal of Oncology 2022:3236058, May 2022.
9. Pei-Yin Chen, Shih-Chi Chao, Pei-Ling Hsieh, Yi-Wen Liao, Pei-Ming Chu, Horng-Jyh Harn, Cheng-Chia Yu. Butylidenephthalide Abrogates the Snail-Induced Cancer Stemness in Oral Carcinomas. International Journal of Molecular Sciences 23(11):6157, May 2022. （本人為通訊作者）
10. Tefera W. Mekonnen, Haile F. Darge, Hsieh-Chih Tsai, Yihenew S. Birhan, Endiries Y. Hanurry, Hailemichael T. Gebrie, Hsiao-Ying Chou, Juin-Yih Lai, Shinn-Zong Lin, Horng-Jyh Harn, Yu-Shuan Chen. Combination of ovalbumin-coated iron oxide nanoparticles and poly(amidoamine) dendrimer-cisplatin nanocomplex for enhanced anticancer efficacy. Colloids and Surfaces B: Biointerfaces 213:112391, May 2022.
11. Ching-Ann Liu, Wei-Hsiu Liu, Hsin-I Ma, Yuan-Hao Chen, Dueng-Yuan Hueng, Wen-Chiuan Tsai, Shinn-Zong Lin, Horng-Jyh Harn, Tzyy-Wen Chiou, Jen-Wei Liu, Jui-Hao Lee, Tsung-Lang Chiu. Interstitial Control-Released Polymer Carrying a Targeting Small-Molecule Drug Reduces PD-L1 and MGMT Expression in Recurrent High-Grade Gliomas with TMZ Resistance. Cancers (Basel) 14(4):1051, Feb 2022.
12. Hsin-Han Yang, I-Tsang Chiang, Jen-Wei Liu, Jeanne Hsieh, Jui-Hao Lee, Huai-En Lu, Hwa-Sung Tso, Yu-Chen Deng, Jo-Chi Kao, Jhen-Rong Wu, Horng-Jyh Harn, Tzyy-Wen Chiou. Anti-Excitotoxic Effects of N-Butylidenephthalide Revealed by Chemically Insulted Purkinje Progenitor Cells Derived from SCA3 iPSCs. International Journal of Molecular Sciences 23(3):1391, Jan 2022. （本人為通訊作者）
13. Tsung-Lang Chiu, R. Baskaran, S-T. Tsai, C-Y. Huang, M-H. Chuang, W-S. Syu, Horng-Jyh Harn, Y-C. Lin, C-H. Chen, P-C. Huang, Y-F. Wang, C-H. Chuang, P-C. Lin, Shinn-Zong Lin. Intracerebral transplantation of autologous adipose-derived stem cells for chronic ischemic stroke: A phase I study. J Tissue Eng Regen Med 16:3–13, Jan 2022. https://doi.org/10.1002/term.3256
14. Hueng-Chuen Fan, Fung-Wei Chang, Jeng-Dau Tsai, Kao-Min Lin, Chuan-Mu Chen, Shinn-Zong Lin, Ching-Ann Liu, Horng-Jyh Harn. Telomeres and Cancer. Life (Basel) 11(12):1405, Dec 2021. （本人為通訊作者）
15. Kang-Yun Lu, K.T.P. Dass, Shinn-Zong Lin, Yu-Hua Tseng, Shih-Ping Liu, Horng-Jyh Harn. n-butylidenephthalide ameliorates high-fat diet-induced obesity in mice and promotes browning through adrenergic response/AMPK activation in mouse beige adipocytes. BBA Mol Cell Biol Lipids 1866(12):159033, Dec 2021. （本人為通訊作者）
16. Tsung-Ming Lee, Cheng-Che Lee, Horng-Jyh Harn, Tzyy-Wen Chiou, M-H. Chuang, C-H. Chen, C-H. Chuang, P-C. Lin, Shinn-Zong Lin. Intramyocardial injection of human adipose-derived stem cells ameliorates cognitive deficit by regulating oxidative stress-mediated hippocampal damage after myocardial infarction. Journal of Molecular Medicine, 1815–1827, Dec 2021.
17. Hsiao-Chien Ting, Hui-I Yang, Horng-Jyh Harn, I-M. Chiu, Hong-Lin Su, Xiang Li, M-F. Chen, Tsung-Jung Ho, C-A. Liu, Y-J. Tsai, T-W. Chiou, Shinn-Zong Lin, Chia-Yu Chang. Coactivation of GSK3β and IGF-1 Attenuates ALS Nerve Fiber Cytopathies in SOD1 Mutant Patient-Derived Motor Neurons. Cells 10(10):2773, Oct 2021.
18. Hsin-Han Yang, Jen-Wei Liu, Jui-Hao Lee, Horng-Jyh Harn, Tzyy-Wen Chiou. Pancreatic Adenocarcinoma Therapeutics Targeting RTK and TGF Beta Receptor. International Journal of Molecular Sciences 22(15):8125, Jul 2021. （本人為通訊作者）
19. Kang-Yun Lu, S-Z. Lin, K.T.P. Dass, W-J. Lin, S-P. Liu, Horng-Jyh Harn. 3-N-butylphthalide protects against high-fat-diet-induced obesity in C57BL/6 mice and increases metabolism in lipid-accumulating cells. Biomed Pharmacother 139:111687, Jul 2021. （本人為通訊作者）
20. Jui-Hao Lee, S-Y. Lin, J-W. Liu, S-Z. Lin, Horng-Jyh Harn, T-W. Chiou. n-Butylidenephthalide Modulates Autophagy to Ameliorate Neuropathological Progress of SCA3 through mTOR Pathway. International Journal of Molecular Sciences 22(12):6339, Jun 2021. （本人為通訊作者）
21. Wei WuLi, Horng-Jyh Harn, Tzyy-Wen Chiou, Shinn-Zong Lin. Chinese herbs and acupuncture to improve cognitive function in Alzheimer's disease. Tzu Chi Medical Journal 33(2):122–127, Feb 2021.
22. Hong-Meng Chuang, Li-Ing Ho, Horng-Jyh Harn, Ching-Ann Liu. Recent Findings on Cell-Based Therapies for COVID-19-Related Pulmonary Fibrosis. Cell Transplantation 30:963689721996217, Jan 2021.
23. Hsin-Han Yang, Yue-Xuan Xu, Jie-Yi Chen, Horng-Jyh Harn, Tzyy-Wen Chiou. N-Butylidenephthalide Inhibits the Phenotypic Switch of VSMCs through Activation of AMPK and Prevents Stenosis in an Arteriovenous Fistula Rat Model. International Journal of Molecular Sciences 21(19):7403, Oct 2020.
24. Kang-Yun Lu, Kingsley Theras Primus Dass, Shinn-Zong Lin, Horng-Jyh Harn, Shih-Ping Liu. The application of stem cell therapy and brown adipose tissue transplantation in metabolic disorders. Cytotherapy 22(10):521–528, Oct 2020. （本人為通訊作者）
25. En-Yi Lin, Yu-Shuan Chen, Yuan-Sheng Li, Syuan-Rong Chen, Chia-Hung Lee, Mao-Hsuan Huang, Hong-Meng Chuang, Horng-Jyh Harn, Hsueh-Hui Yang, Shinn-Zong Lin, Dar-Fu Tai, Tzyy-Wen Chiou. Liposome Consolidated with Cyclodextrin Provides Prolonged Drug Retention Resulting in Increased Drug Bioavailability in Brain. International Journal of Molecular Sciences 21(12):4408, Jun 2020.
26. Chia-Yu Chang, Hsiao-Chien Ting, Ching-Ann Liu, Hong-Lin Su, Tzyy-Wen Chiou, Shinn-Zong Lin, Horng-Jyh Harn, Tsung-Jung Ho. Induced Pluripotent Stem Cell (iPSC)-Based Neurodegenerative Disease Models for Phenotype Recapitulation and Drug Screening. Molecules 25(8):2000, Apr 2020.
27. Yu-Shuan Chen, Zhen-Xiang Hong, Shinn-Zong Lin, Horng-Jyh Harn. Identifying Therapeutic Targets for Spinocerebellar Ataxia Type 3/Machado-Joseph Disease through Integration of Pathological Biomarkers and Therapeutic Strategies. International Journal of Molecular Sciences 21(9):3063, Apr 2020. （本人為通訊作者）
28. Wei WuLi, Sheng-Tzung Tsai, Tzyy-Wen Chiou, Horng-Jyh Harn. Human-Induced Pluripotent Stem Cells and Herbal Small-Molecule Drugs for Treatment of Alzheimer's Disease. International Journal of Molecular Sciences 21(4):1327, Feb 2020. https://doi.org/10.3390/ijms21041327 （本人為通訊作者）
29. Hong-Meng Chuang, Mao-Hsuan Huang, Yu-Shuan Chen, Horng-Jyh Harn. SOX2 for Stem Cell Therapy and Medical Use: Pros or Cons? Cell Transplantation, Jan 2020. https://doi.org/10.1177/0963689720907565 （本人為通訊作者）
30. Kang-Yun Lu, Kingsley Theras Primus Dass, Sheng-Feng Tsai, Hong-Meng Chuang, Shinn-Zong Lin, Shih-Ping Liu, Horng-Jyh Harn. Clinical Application Potential of Small Molecules that Induce Brown Adipose Tissue Thermogenesis by Improving Fat Metabolism. Cell Transplantation, Jan 2020. https://doi.org/10.1177/0963689720927394 （本人為通訊作者）