高毓儒 特聘研究員 Dr. Kou, Yu Ru
E-mail：gaoyuru0801@gmail.com
分機：15933
University of Kentucky, USA. Ph.D.
專長：Translation Medicine, Cellular and Molecular Biology, Neurobiology, Critical Care Medicine, Clinical Epidemiology, Clinical Research
經歷：
國立陽明大學 生理學研究所 教授 (1991-2022)
國立陽明大學 急重症醫學研究所 教授 (2008-2022)
花蓮慈濟醫院 教學部 客座教授 (2019-2020)
台北市市立聯合醫院 研究員 (2006-2015)
行政院國科會生物處 形態及生理醫學學門 學門召集人(2009-2011)
美國凱斯西儲大學附設醫院重症加中心 研究員 (1989-1991)
研究興趣：
(1)肺細胞發炎反應與凋亡的調控－以細胞培養、各種蛋白質定量、免疫染色、PCR、微陣列基因分析、基因轉殖等分子細胞生物學的技術進行研究。用上皮、血管內皮、巨噬細胞等肺細胞為研究題材。
(2)多種肺損傷與肺發炎的成因與治療－以各種蛋白質定量、免疫染色、PCR、組織切片等方法進行研究。用大鼠與小鼠為研究題材。
(3)急重症醫學及呼吸治療－以呼吸生理訊號及肺功能機械學測量、各種蛋白質定量、免疫染色、PCR、組織切片等方法進行研究。用大鼠與小鼠為研究題材，並操作人體實驗。
(4)醫學流行病學及臨床醫學研究
1. Yu WK, Chen YC, Chen WC, Su VY, Yang KY, Kou YR* Influencing factors for tracheostomy in patients with acute traumatic C3-C5 spinal cord injury and acute respiratory failure. J Chin Med Assoc. 2021 Dec 21. (Online ahead of print)
2. Tsao PC, Lin CH, Lee YS, Chen WY, Jeng MJ, Kou YR*. Efficacy of intratracheal budesonide-surfactant combined therapy in surfactant-insufficient rat lungs with lipopolysaccharide insult. J Chin Med Assoc. 2021 Aug 1;84(8):783-790.
3. Wu CK, Lin JF, Lee TS, Kou YR, Tarng DC. Role of TRPA1 in tissue damage and kidney disease. Int J Mol Sci. 2021 Mar 26;22(7):3415.
4. Wu CK, Wu CL, Lee TS, Kou YR*, Tarng DC. Renal tubular epithelial TRPA1 acts as an oxidative stress sensor to mediate ischemia-reperfusion-induced kidney injury through MAPKs/NF-κB signaling. Int J Mol Sci. 2021 Feb 25;22(5):2309.
5. Ko HK, Lin AH, Perng DW, Lee TS, Kou YR*. Lung epithelial TRPA1 mediates lipopolysaccharide-induced lung inflammation in bronchial epithelial cells and mice. Front Physiol. 2020 Nov 17;11:596314.
6. Hu PA, Chen CH, Guo BC, Kou YR, Lee TS. Bromelain confers protection against the non-alcoholic fatty liver disease in male C57bl/6 mice. Nutrients. 2020 May 18;12(5):1458.
7. Wu KM, Chi CW, Lai JC, Chen YJ, Kou YR*. TLC388 induces DNA damage and G2 phase cell cycle arrest in human non-small cell lung cancer cells. Cancer Control. 2020 Jan-Dec;27(1):1073274819897975.
8. Wu CK, Wu CL, Su TC, Kou YR, Kor CT, Lee TS, Tarng DC. Renal tubular TRPA1 as a risk factor for recovery of renal function from acute tubular necrosis. J Clin Med. 2019 Dec 11;8(12):2187.
9. Wu KM, Liao HF, Chi CW, Kou YR*, Chen YJ. Wasabi compound 6-(Methylsulfinyl) Hexyl Isothiocyanate induces cell death with coexisting mitotic arrest and autophagy in human chronic myelogenous leukemia K562 cells. Biomolecules. 2019 Nov 23;9(12):774.
10. Wu KM, Chang WK, Chen CH, Kou YR*. Expression of IL-1β, HMGB1, HO-1, and LDH in malignant and non-malignant pleural effusions. Respir Physiol Neurobiol. 2020 Jan;272:103330.
11. Pan SW, Yen YF, Feng JY, Chuang PH, Su VY, Kou YR, Su WJ, Chan YJ. Opposite effects of statins on the risk of tuberculosis and herpes zoster in patients with diabetes: A population-based cohort study. Br J Clin Pharmacol. 2020 Mar;86(3):569-579.
12. Chen CH, Zhao JF, Hsu CP, Kou YR, Lu TM, Lee TS. The detrimental effect of asymmetric dimethylarginine on cholesterol efflux of macrophage foam cells: Role of the NOX/ROS signaling. Free Radic Biol Med. 2019 Nov 1;143:354-365.
13. Chen YC, Pan SW, Yu WK, Shen HS, Chuang FY, Kou YR*. Authors' reply to comments on "Post-intensive care unit respiratory failure in older patients liberated from intensive care unit and ventilator". Geriatr Gerontol Int. 2019 Aug;19(8):839-840.
14. Chen PK, Shih CC, Lin FC, Perng DW, Chou KT, Kou YR*, Ko HK. Prolonged use of noninvasive positive pressure ventilation after extubation among patients in the intensive care unit following cardiac surgery: The predictors and its impact on patient outcome. Sci Rep. 2019 Jul 2;9(1):9539.
15. Su KC, Ko HK, Chou KT, Hsiao YH, Su VY, Perng DW, Kou YR*. An accurate prediction model to identify undiagnosed at-risk patients with COPD: a cross-sectional case-finding study. NPJ Prim Care Respir Med. 2019 May 28;29(1):22.
16. Chen YC, Yu WK, Ko HK, Pan SW, Chen YW, Ho LI, Bien MY, Wang JH, Chan YJ, Kou YR*. Post-intensive care unit respiratory failure in older patients liberated from intensive care unit and ventilator: The predictive value of the National Early Warning Score on intensive care unit discharge. Geriatr Gerontol Int. 2019 Apr;19(4):317-322.
17. Lin AH, Liu MH, Ko HK, Perng DW, Lee TS, Kou YR*. Menthol cigarette smoke induces more severe lung inflammation than non-menthol cigarette smoke does in mice with subchronic exposure - role of TRPM8. Front Physiol. 2018 Dec 18;9:1817.
18. Hsiao YH, Tseng CM, Su KC, Chen WC, Wu MT, Wu YC, Chang SC, Lee YC, Kou YR*, Perng DW. Glycopyrronium bromide inhibits lung inflammation and small airway remodeling induced by subchronic cigarette smoke exposure in mice. Respir Physiol Neurobiol. 2018 Feb;249:16-22.
19. Pan SW, Yen YF, Kou YR, Chuang PH, Su VY, Feng JY, Chan YJ, Su WJ. The risk of TB in patients with type 2 diabetes initiating metformin vs sulfonylurea treatment. Chest. 2018 Jun;153(6):1347-1357.
20. Su KC, Kou YR, Lin FC, Wu CH, Feng JY, Huang SF, Shiung TF, Chung KC, Tung YH, Yang KY, Chang SC. A simplified prevention bundle with dual hand hygiene audit reduces early-onset ventilator-associated pneumonia in cardiovascular surgery units: An interrupted time-series analysis. PLoS One. 2017 Aug 2;12(8):e0182252.
21. Pan SW, Yen YF, Kou YR, Chuang PH, Feng JY, Chan YJ, Su WJ. The impact of cancer development on the risk of mycobacterial diseases among rheumatoid arthritis patients. Epidemiol Infect. 2017 Sep;145(12):2482-2490.
22. Lin CH, Jeng MJ, Yang YC, Hsiao YH, Kou YR*. Comparison of different dosing strategies of intratracheally instilled budesonide on meconium injured piglet lungs. Pediatr Pulmonol. 2017 Jul;52(7):891-899.
23. Lin AH, Liu MH, Ko HB, Perng DW, Lee TS, Kou YR*. Inflammatory effects of menthol vs. non-menthol cigarette smoke extract on humanlLung epithelial cells: a double-hit on TRPM8 by reactive oxygen species and menthol. Front Physiol. 2017 Apr 27;8:263.
24. Tsao PC, Lee YS, Jeng MJ, Hsu JW, Huang KL, Tsai SJ, Chen MH, Soong WJ, Kou YR*. Additive effect of congenital heart disease and early developmental disorders on attention-deficit/hyperactivity disorder and autism spectrum disorder: a nationwide population-based longitudinal study. Eur Child Adolesc Psychiatry. 2017 Nov;26(11):1351-1359.
25. Liu MH, Lin AH, Ko HK, Perng DW, Lee TS, Kou YR*. Prevention of bleomycin-induced pulmonary inflammation and fibrosis in mice by paeonol. Front Physiol. 2017 Mar 31;8:193.
26. Su KC, Chou KT, Hsiao YH, Tseng CM, Su VY, Lee YC, Perng DW, Kou YR*. Measuring (1,3)-β-D-glucan in tracheal aspirate, bronchoalveolar lavage fluid, and serum for detection of suspected Candida pneumonia in immunocompromised and critically ill patients: a prospective observational study. BMC Infect Dis. 2017 Apr 8;17(1):252.