許澤方 助理研究員

 

  許澤方 助理研究員 Dr. Hsu, Che-Fang 
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Ext：15735  或 簡碼#17445

學歷：
National Dong Hwa University. Ph.D.
專長 Expertise：Translational Medicine, Cellular and Molecular Biology, Oncology

 

經歷:

Center for Prevention and Therapy of Gynecological Cancers, Department of Medical Research, Hualien Tzu Chi Hospital, Postdoctoral fellow


研究興趣 Interest：     

(1) The role of ovulation follicular fluid factors in the development of endometriosis.

(2) Interaction between endometriotic lesions with KRAS mutation and ovulation effect.

(3) The role of immune checkpoints (PD1 and PDL1) in the transformation stage of endometriosis.

(4) Interaction between type II ovarian cancer (HGSC) and ovulation effect on peritoneal metastasis.

(5) Establishment of animal models for gynecological pathology.

 

(1)排卵濾泡液各因子對子宮內膜異位症發育之角色。

(2)具有KRAS突變的子宮內膜異位症病變與排卵效應的交互作用。

(3)免疫檢查點(PD1與PDL1)對於子宮內膜異位症轉化階段的作用。

(4)第二型卵巢癌(HGSC)與排卵效應於腹腔轉移的交互作用。

(5)婦科病理動物模型的建立。

 

成果發表(5年內) Publication (in five years)：

1. 

Che-Fang Hsu, Vaishnavi Seenan, Liang-Yuan Wang, Tang-Yuan Chu (2022, Jun). Ovulation Enhances Intraperitoneal and Ovarian Seedings of High-Grade Serous Carcinoma Cells Originating from the Fallopian Tube: Confirmation in a Bursa-Free Mouse Xenograft Model. International Journal of Molecular Sciences, 23(11):6211. (SCI, Q1, 69/296 / Biochemistry & Molecular Biology).

2.

Che-Fang Hsu, Aye Aye Khine, Hsuan-Shun Huang, Tang-Yuan Chu (2022, Jun). The Double Engines and Single Checkpoint Theory of Endometriosis. Biomedicines, 10(6):1403. (SCI, Q1: Pharmacology & Pharmacy).

3.

Chee-Hing Yang, Che-Fang Hsu, Xiang-Qing Lai, Yu-Ru Chan 1, Hui-Chun Li, Shih-Yen Lo (2022, Oct). Cellular PSMB4 Protein Suppresses Influenza A Virus Replication through Targeting NS1 Protein. Viruses, 2022 Oct 17;14(10):2277.

4.

Jie Mei, Huixiang Tian, Hsuan-Shun Huang, Che-Fang Hsu, Yuligh Liou, Nayiyuan Wu, Wei Zhang, Tang-Yuan Chu (2021, May). Cellular models of development of ovarian high-grade serous carcinoma: A review of cell of origin and mechanisms of carcinogenesis. Cell Proliferation, 2021 May;54(5): . (SCI, Q1, 48/195 CELL BIOLOGY).

5.

Che-Fang Hsu, Pao-Chu Chen, Vaishnavi Seenan, Dah-Ching Ding and Tang-Yuan Chu (2021, Jan). Ovulatory Follicular Fluid Facilitates the Full Transformation Process for the Development of High-Grade Serous Carcinoma. Cancers, 2021, 13(3), 468-490. (SCI, 31/229 (Q1) / Oncology).

6.

 Shian-Ren Lin, Chia-Hsiang Chang, Che-Fang Hsu, May-Jwan Tsai, Henrich Cheng, Max K Leong, Ping-Jyun Sung, Jian-Chyi Chen, and Ching-Feng Weng* (2020, Mar). Natural compounds as potential adjuvants to cancer therapy: preclinical evidence. British Journal of Pharmacology. (SCI, 13/330 (Q1), Pharmacology).

7.

Hsu CF, Huang HS, Chen PC, Ding DC, Chu TY. (2019, Mar). IGF-axis confers transformation and regeneration of fallopian tube fimbria epithelium upon ovulation. EBioMedicine, 41:597-609. (SCI, 13/133 (Q1), MEDICINE, RESEARCH & EXPERIMENTAL).