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Dr. Pang, Cheng-Yoong

		Dr. Pang, Cheng-Yoong
		E-mail：Email住址會使用灌水程式保護機制。你需要啟動Javascript才能觀看它
		Ext：15613
		National Yang Ming University, Taiwan. Ph.D.
		Expertise：Translational Medicine、Mitochondria、Stem Cell Regeneration Medicine

Interest：

Our laboratory focus on developing and evaluating the effects of various mesenchymal stem cells transplantation on the outcome of brain injuries, spinal cord injury, Parkinson’s disease, and etc.. We have successfully launched a Phase I/II trial evaluating intracranial transplantation of autologous CD34+ bone marrow stem cells in patients suffering from chronic ischemic cerebral stroke. The trial has performed 6 transplantations, and the result has so far proven the safety and feasibility of intracranial delivery of stem cells, prepared in our GMP facility.

Besides stem cell research, we are also interested in studying the protection mechanisms of growth factors (e.g., G-CSF), neuropeptides (e.g., urocortin), and herbal extracts on cellular damage caused by oxidative stress, neuro-degeneration diseases, and neurotrauma.

Publication (in five years)：

1.	Tsai S, Chu S, Liu S, Pang C, Hou T, Lin S, Chen S. (2016, Dec). Neuroprotection of Granulocyte Colony - Stimulating Factor for Early Stage Parkinson’s Disease.. Cell Transplant., doi: 10.3727/096368916X694247.. (SCI)..
2.	Tseng TL, Chen MF, Liu CH, Pang CY, Hsu YH, Lee TJ*. (2016, Apr). Induction of endothelium-dependent constriction of mesenteric arteries in endotoxemic hypotensive shock.. Br J Pharmacol., 173(7):1179-95.. (SCI, 24/255 (Pharmacology & Pharmacy)).
3.	Liew HK, Cheng HY, Huang LC, Li KW, Peng HF, Yang HI, Lin PB, Kuo JS, Pang CY*. (2016, Jan). Acute Alcohol Intoxication Aggravates Brain Injury Caused by Intracerebral Hemorrhage in Rats . Journal of Stroke and Cerebrovascular Diseases, 25(1),15–25. (SCI, 194/252, NEUROSCIENCES ). 本人為通訊作者.
4.	Chen TT, Wu LS, Hsu PW, Pang CY, Lee KM, Cheng PC, Peng SY*. (2015, Aug). Mitochondrial dynamics in the mouse liver infected by Schistosoma mansoni.. Acta Trop., 148:13-23.. (SCI, 13/36, PARASITOLOGY).
5.	Chiu SC, Lin YJ, Huang SY, Lien CF, Chen SP, Pang CY, Lin JH, Yang KT*. (2015, Jul). The Role of Intermittent Hypoxia on the Proliferative Inhibition of Rat Cerebellar Astrocytes.. PLoS One., 10(7):e0132263.. (SCI, 8/56, MULTIDISCIPLINARY SCIENCES).
6.	Liew HK, Kuo JS, Wang JY, Pang CY* (2015, Jun). Granulocyte-Colony Stimulating Factor Increases Cerebral Blood Flow via a NO Surge Mediated by Akt/eNOS Pathway to Reduce Ischemic Injury. The Scientific World Journal, 2015:657932. (SCI, 16/55, MULTIDISCIPLINARY SCIENCES). MOST 96-2320-b-016-014-my3. 本人為通訊作者.
7.	Huang HY, Chiu TL, Chang HF, Hsu HR, Pang CY, Liew HK, Wang MJ.* (2015, May). Epigenetic Regulation Contributes to UrocortinEnhanced Midbrain Dopaminergic Neuron Differentiation. Stem Cells, 33(5):1601-17. MOST 101-2320-B-303-001.
8.	Liew HK, Huang LC, Yang HI, Peng HF, Li KW, Tsai AP, Chen SY, Kuo JS, Pang CY*. (2015, May). Therapeutic effects of human urocortin-1, -2 and -3 in intracerebral hemorrhage of rats.. Neuropeptides., pii: S0143-4179(15)00055-4. (SCI, 68/128, ENDOCRINOLOGY & METABOLISM). 本人為通訊作者.
9.	Li CJ, Sun LY, Pang CY*. (2015, Apr). Synergistic protection of Nacetylcysteine and ascorbic acid 2-phosphate on human mesenchymal stem cells against mitoptosis, necroptosis and apoptosis.. Sci Rep., 24;5:9819.. (SCI, 5/56). 本人為通訊作者
10.	Chou CL, Pang CY, Lee TJ, Fang TC*. (2015, Mar). Beneficial effects of calcitriol on hypertension, glucose intolerance, impairment of endotheliumdependent vascular relaxation, and visceral adiposity in fructose-fed hypertensive rats.. PLoS One., 10(3):e0119843.. (SCI, 8/56, MULTIDISCIPLINARY SCIENCES).
11.	Chiu SC, Huang SY, Chang SF, Chen SP, Chen CC, Lin TH, Liu HH, Tsai TH, Lee SS, Pang CY, Hsieh TF. (2014, Sep). Potential therapeutic roles of tanshinone IIA in human bladder cancer cells. Int J Mol Sci, 15(9):15622-15637. (SCI, 52/148, CHEMISTRY, MULTIDISCIPLINARY). 本人為通訊作者.
12.	Li-Yi Sun, Dian-Kun Li, Pao-Jen Chen, Yu-Yu Joyce Ho, Jon-Son Kuo, Ching-Feng Cheng, Kuei-Fang Lee, Yao-Jen Chang and Cheng-Yoong Pang (2014, Apr). Expansion of Semi-Automatic Processed Human Adipose-Derived Stem Cells in Medium Supplemented with Autologous Serum and Antioxidants. J Stem Cell Res Ther, 4: 193. . 本人為通訊作者
13.	Chiu SC, Huang SY, Chen SP, Su CC, Chiu TL, Pang CY. (2013, Dec). Tanshinone IIA inhibits human prostate cancer cells growth by induction of endoplasmic reticulum stress in vitro and in vivo. Prostate Cancer and Prostatic Diseases, 16(4), 315-322. (SCI, 20/77, UROLOGY & NEPHROLOGY; 94/203, ONCOLOGY). 本人為通訊作者.
14.	Pang CY, Chiu SC, Harn HJ, Zhai WJ, Lin SZ, Yang HH. (2013, Sep). Proteomic-based identification of multiple pathways underlying nbutylidenephthalide-induced apoptosis in LNCaP human prostate cancer cells. Food and Chemical Toxicology, 59, 281-288. (SCI, 21/123, FOOD SCIENCE & TECHNOLOGY; 34/87, TOXICOLOGY). 本人為第一作者.
15.	Sun LY, Pang CY, Li DK, Liao CH, Huang WC, Wu CC, Chou YY, Li WW, Chen SY, Liu HW, Chang YJ, Cheng CF. (2013, Aug). Antioxidants cause rapid expansion of human adipose-derived mesenchymal stem cells via CDK and CDK inhibitor regulation. Journal of Biomedical Science, 20(1), 53. (SCI, 49/124, MEDICINE, RESEARCH & EXPERIMENTAL). 本人為第一作者.
16.	Liao CH, Chen SY, Kuo JS, Pang CY. (2013, Jun). Reduction of Motor Disorder in 6-OHDA-Induced Severe Parkinsonism Rats by Post Treatment with Granulocyte-Colony Stimulating Factor.. Chinese Journal of Physiology, 56(3), 147-154. (SCI, 65/81, PHYSIOLOGY). 本人為通訊作者.
17.	Chuang JY, Liew HK, Pang CY, Kuo JS (2013, Mar). Size-controllable striatal lesion model for evaluation of neuroprotective agents in rats.. Tzu Chi Medical Journal, 25(1), 23-28.
18.	Chou CL, Pang CY, Lee TJ, Fang TC. (2013, Feb). Direct renin inhibitor prevents and ameliorates insulin resistance, aortic endothelial dysfunction and vascular remodeling in fructose-fed hypertensive rats.. HYPERTENSION RESEARCH, 36(2),123-128. (SCI, 26/65, PERIPHERAL VASCULAR DISEASE ).
19.	Yang JR, Liao CH, Pang CY, Huang LL, Chen YL, Shiue YL, Chen LR. (2013, Feb). Transplantation of porcine embryonic stem cells and their derived neuronal progenitors in a spinal cord injury rat model.. Cytotherapy, 15(2), 201-208. (SCI, 45/165, BIOTECHNOLOGY & APPLIED MICROBIOLOGY).

Dr. Wang, Mei-Jen

		Dr. Wang, Mei-Jen
		E-mail：Email住址會使用灌水程式保護機制。你需要啟動Javascript才能觀看它
		Ext：15616
		National Taiwan University, Taiwan. Ph.D.
		Expertise：Neuroimmunology, Molecular neurobiology, Neurodegeneration & regeneration, Signal transduction

Experience：Neuropharmacology Section, NIEHS/NIH. Postdoctoral Fellow
Department of Education and Research, Taichung Veterans General Hospital. Postdoctoral Fellow

Interest：

Our current interests focus on:

1. The role of microglia (an immune cell in the brain) in the neurodegenerative diseases, such as Parkinson’s disease.

2. The effect of Parkin gene mutation in dopaminergic neurons exposed to oxidative stress, neurotoxins and inflammation.

3. The function of neuropeptide, urocortin, on neuroprotection, neuronal differentiation of neural stem cells and anti-inflammation.

4. Regulation of neuron-derived exosomes on microglial activation.

Publication (in five years)：

1.	Huang HY, Chang HF, Tsai MJ, Chen JS, Wang MJ* (2016) 6-Mercaptopurine attenuates tumor necrosis factor-a production in microglia through Nur77-mediated transrepression and PI3K/Akt/mTOR signaling-mediated translational regulation. J Neuroinflammation 13:78. *(corresponding author)**.
2.	Chou YC, Chang MY, Wang MJ, Liu HC, Chang SJ, Harnod T, Hung CH, Lee HT, Shen CC, Chung JG (2015) Phenethyl isothiocyanate alters the gene expression and the levels of protein associated with cell cycle regulation in human glioblastoma GBM8401 cells. Environ Toxicol DOI: 10.1002/tox.22224.
3.	Chou YC, Chang MY, Wang MJ, Yu FS, Liu HC, Harnod T, Hung CH, Lee HT, Chung JG (2015) PEITC inhibits human brain glioblastoma GBM8401 cell migration and invasion through the inhibition of uPA, RhoA, and Ras with inhibition of MMP-2, -7 and -9 gene expression. Oncol Rep 34:2489-2496.
4.	Huang HY, Chiu TL, Chang HF, Hsu HR, Pang CY, Liew HK, Wang MJ* (2015) Epigenetic regulation contributes to urocortin-enhanced midbrain dopaminergic neuron differentiation. Stem Cells 33:1601-1617. *(corresponding author).**
5.	Chou YC, Chang MY, Wang MJ, Harnod T, Huang CH, Lee HT, Shen CC, Chung JG (2015) PEITC induces apoptosis of human brain glioblastoma GBM8401 cells through the extrinsic- and intrinsic-signaling pathways. Neurochem Int 81:32-40.
6.	Tsai MJ, Yang-Yen HF, Chiang MK, Wang MJ, Wu SS, Chen SH (2014) TCTP is essential for b-cell proliferation and mass expansion during development and b-cell adaptation in response to insulin resistance. Endocrinology 155: 392-404.
7.	Huang HY, Liu DD, Chang HF, Chen WF, Hsu HR, Kuo JS, Wang MJ* (2012) Histone deacetylase inhibition mediates urocortin-induced antiproliferation and neuronal differentiation in neural stem cells. Stem Cells 30: 2760-2773. *(corresponding author)**.
8.	Chiu TL, Wang MJ, Su CC (2012) The treatment of glioblastoma multiforme through activation of microglia and TRAIL induced by rAAV2-mediated IL-12 in a syngeneic rat model. J Biomed Sci 19:45
9.	Chiu SC, Chen SP, Huang SY, Wang MJ, Lin SZ, Harn HJ, Pang CY (2012) Induction of apoptosis coupled to endoplasmic reticulum stress in human prostate cancer cells by n-butylidenephthalide. PLoS ONE 7: e33742
10.	Liew HK, Pang CY, Hsu CW, Wang MJ, Li TY, Peng HF, Kuo JS, Wang JY (2012) Systemic administration of urocortin after intracerebral hemorrhange reduces neurological deficits and neuroinflammation in rats. J Neuroinflammation 9:13
11.	Liew HK, Hsu CW, Wang MJ, Kuo JS, Li TY, Peng HF, Wang JY, Pang CY (2012) Therapeutic benefit of urocortin in rats with intracerebral hemorrhage. J. Neurosurg. 116: 193-200.

Dr. Yang, Hsueh-Hui

		Dr. Yang, Hsueh-Hui
		E-mail：Email住址會使用灌水程式保護機制。你需要啟動Javascript才能觀看它
		Ext：13052
		The Ohio State University, USA. Ph.D.
		Expertise：Proteomics, Mass spectrometry, Electrochemistry

Interest：

Identification of new markers of disease
Finding novel therapeutic targets
Investigation of the underlying pathogenesis

Publication (in five years)：

1.	Liu, S.-Y.; Liao, C.-K.; Lo, C.-T.; Yang, H.-H.; Lin, K.-C.; Peng, K.-C. “Chrysophanol is Involved in the Biofertilization and Biocontrol Activities of Trichoderma” Physiol. Mol. Plant Pathol. 2016, 96, 1-7.
2.	Yang, H.-H.; Ting, H.-H.; Shih, Y. “Self-Validated Detection of Hydroquinone in Medicated Cosmetic Products Using a Preanodized Screen-Printed Ring Disk Carbon Electrode” Anal. Methods 2016, 8, 5495-5502.
3.	Yu, M.-H.; Yang, H.-H.; Naziruddin, A.-R.; Kanne, S.; Wang, B.-H.; Liu, F.-C.; Lin, I. J. B.; Lee, G.-H. “Formation of NH,NR N-Heterocyclic Carbene Complexes through Mercuration of Mono-N-substituted Benzimidazoles” Eur. J. Inorg. Chem. 2016, 29, 4829-4834.
4.	Shu, H.-Y.; Lin, L.-C.; Lin, T.-K.; Chen, H.-P.; Yang, H.-H.; Peng, K.-C.; Lin, G.-H.* “Transcriptional regulation of the iac locus from Acinetobacter baumannii by the phytohormone indole-3-acetic acid” Antonie van Leeuwenhoek 2015, 107, 1237-1247.
5.	Chen, P.-Y.; Yang, H.-H.; Huang, C.-C.; Chen, Y.-H.; Shih, Y.* “Involvement of Cu(II) in the Electrocatalytic Reduction of Bromate on a Disposable Nano-Copper Oxide Modified Screen-Printed Carbon Electrode: Hair Waving Products as an Example” Electrochim Acta 2015, 161, 100-107.
6.	Chen, Y.-R.; Chang, K.-T.; Tsai, M.-J.; Lee, C.-H.; Huang, K.-J.; Cheng, H; Ho, Y.-P.; Chen, J.-C.; Yang, H.-H.; Weng, C.-F.* “Antrodia Cinnamomea Profoundly Exalted the Reversion of Activated Hepatic Stellate Cells by the Alteration of Cellular Proteins” Food Chem. Toxicol. 2014, 69, 150-162.
7.	Yang, H.-H.; Chen, P.-Y.; Ho, P.-H.; Shih, Y* “Direct Analysis of Mercury in Cosmetics Using Screen-Printed Silver Electrodes and Flow Injection Analysis” J. Electrochem. Soc. 2014, 161, 137-142.
8.	Marthandam, A. S.; Yang, H.-H.; Lo, C.-T.; Lin, H.-S.; Liu, S.-Y.; Peng, K.-C. “Characterization of a Novel Resistance-Related Deoxycytidine Deaminase from Brassica oleracea var. capitata” J. Agric. Food Chem. 2014, 62, 1796-1801.
9.	Pang, C.-Y.; Chiu, S.-C.; Harn, H.-J.; Zhai, W.-J.; Lin, S.-Z.; Yang, H.-H.* “Proteomic-Based Identification of Multiple Pathways underlying n-Butylidenephthalide-Induced Apoptosis in LNCaP Human Prostate Cancer Cells” Food Chem. Toxicol. 2013, 59, 281-288.
10.	Yang, H.-H.; Lu, K.-H.; Lin, Y.-F.; Tsai, S.-H.; Chakraborty, S.; Zhai, W.-J.; Tai, D.-F. “Depletion of Albumin and Immunoglobulin G from Human Serum Using Epitope-Imprinted Polymers as Artificial Antibodies” J. Biomed. Mater. Res. A 2013, 101, 1935-1942.
11.	Yang, H.-H.; Chien, C.-H.; Yang, C.-C.; Liu, F.-C.; Chang, A. H. H.; Lee, G.-H.; Peng, S.-M. “Syntheses and Structures of Zr₄ Tetrahedral Clusters Containing Direct Zr–Zr Bonds: the Missing Cluster in the Series Zr_n (n = 2–6)” Dalton Trans. 2013, 42, 1168-1173.

Dr. Liew, Hock-Kean

		Dr. Liew, Hock-Kean
		E-mail：Email住址會使用灌水程式保護機制。你需要啟動Javascript才能觀看它
		Ext：15911
		National Defense Medical College, Taiwan. Ph.D.
		Expertise：System Biology, Neuroscience,Biomaterial & Scaffold, Brain Injury

Interest：

Ischemic stroke is a major cause of morbidity and mortality worldwide. To date, no effective treatment is available to reverse the brain damage due to the difficulty to regenerate the matured neuron lost. Over the past few years, though the brain injury platform that we created (cerebral ischemic and cerebral hemorrhagic model), we are trying to establish new drugs and methods to reduce the neurological injury after brain injury. We demonstrated that G-CSF, urocortin and the Neural progenitor cells (NPCs) might possess beneficial effects against brain injury. Recently, our study focus on the combination of urocortin and the NPCs to treat cerebral ischemia. NPCs are considered the ultimate lineage precursors to all neuronal and glial cells. Because of their ability to self-renew, NPCs have promise for treatment of neurological diseases by transplantation therapy, and has been shown to promote recovery of neuronal functions after stroke. However, the disruption of the tissue architecture after brain injury limits the transplant efficacy. Besides, only a small proportion of grafted cells survived in the ischemic brain and rare differentiation to mature neurons. This massive loss of stem cells and rare differentiation to mature neurons post-engraftment is an impediment that lessens the effectiveness of cell transplantation therapy. Urocortin (UCN), a 40 amino acid peptide, which was first identified in rat midbrain. The function of this neuropeptide is to regulate neuroendocrine, autonomic, and immunologic responses to stress. Our results showed that, preconditioning with UCN conferred cytoprotection on NPCs and promoted their differentiation in an in vitro ischemia/reperfusion model. Therefore, we intended to clarify the role of UCN in modulating the NPCs survival, differentiation and the therapeutic efficacy of transplanted NPCs after chronic cerebral I/R injury. This study will provide a new insight into the potential of UCN by increasing survival and neuronal differentiation of transplanted NPCs, to repair the adult brain after chronic ischemic stroke in the future.

Publication (in five years)：

1.	Moderate Ethanol Pre-treatment Mitigates ICH-Induced Injury via ER Stress Modulation in Rats. Lin PB, Wang PK, Pang CY, Hu WF, Tsai AP, Oblak AL, Liew HK. Front Mol Neurosci. 2021 Jun 25;14:682775. doi: 10.3389/fnmol.2021.682775. eCollection 2021. PMID: 34248500 Free PMC article.
2.	A Role for Endoplasmic Reticulum Stress in Intracerebral Hemorrhage. Mohammed Thangameeran SI, Tsai ST, Hung HY, Hu WF, Pang CY, Chen SY, Liew HK*. Cells. 2020 Mar 19;9(3):750. doi: 10.3390/cells9030750. PMID: 32204394 Free PMC article.
3.	The Role of Urocortins in Intracerebral Hemorrhage. Choy KW, Tsai AP, Lin PB, Wu MY, Lee C, Alias A, Pang CY, Liew HK*. Biomolecules. 2020 Jan 7;10(1):96. doi: 10.3390/biom10010096. PMID: 31935997 Free PMC article.
4.	Harnessing Neurogenesis and Neuroplasticity with Stem Cell Treatment for Addictive Disorders. Tsai ST, Liew HK, Li HM, Lin SZ, Chen SY. Cell Transplant. 2019 Sep-Oct;28(9-10):1127-1131. doi: 10.1177/0963689719859299. Epub 2019 Jul 4. PMID: 31271057 Free PMC article.
5.	Over-Activated Proteasome Mediates Neuroinflammation on Acute Intracerebral Hemorrhage in Rats. Liew HK*, Hu WF, Lin PB, Wang PK, Tsai AP, Pang CY, Chen TY. Cells. 2019 Oct 27;8(11):1326. doi: 10.3390/cells8111326. PMID: 31717886 Free PMC article.
6.	Brain Magnetic Resonance Imaging of Intracerebral Hemorrhagic Rats after Alcohol Consumption. Huang LC, Liew HK, Cheng HY, Kuo JS, Hsu WL, Pang CY. J Stroke Cerebrovasc Dis. 2018 Dec;27(12):3493-3502. doi: 10.1016/j.jstrokecerebrovasdis.2018.08.022. Epub 2018 Sep 8. PMID: 30205999
7.	Delayed formation of hematomas with ethanol preconditioning in experimental intracerebral hemorrhage rats. Cheng HY, Huang LC, Peng HF, Kuo JS, Liew HK, Pang CY. Ci Ji Yi Xue Za Zhi. 2018 Jan-Mar;30(1):5-9. doi: 10.4103/tcmj.tcmj_184_17. PMID: 29643709 Free PMC article.
8.	Collagenase-Induced Rat Intra-Striatal Hemorrhage Mimicking Severe Human Intra-Striatal Hemorrhage. Huang LC, Liew HK**, Cheng HY, Peng HF, Yang HI, Kuo JS, Hsu WL, Pang CY. Chin J Physiol. 2017 Oct 31;60(5):259-266. doi: 10.4077/CJP.2017.BAF478. PMID: 28950689

Dr. Liu, Hsin-Tzu

		Dr. Liu, Hsin-Tzu
		E-mail：Email住址會使用灌水程式保護機制。你需要啟動Javascript才能觀看它
		Ext：12132
		Tzu Chi University, Taiwan. Ph.D.
		Expertise：Urinary Biomarkers, Pharmacology & Physiology, Molecular Genetics

Experience：Department of Medical Research. Assistant Researcher
Center for Medical Genetics. Genetic Counsellor

Interest：

The main research focus in the laboratory is the investigation of the pathophysiological mechanisms underlying overactive bladder (OAB) syndrome. Our interest in this topic developed through elucidation of the roles of sensory nerve proteins (e.g., nerve growth factor; NGF), sensory nerve receptors (e.g., TRPV1 and P2X3), inflammation-related substances (e.g., prostaglandin E2; PGE2), and oxidative stress-related proteins in the bladders of patients with OAB. We use protein analysis techniques, such as enzyme-linked immunoassay (ELISA) and immunohistochemistry, and molecular biology techniques, such as real-time polymerase chain reaction (real-time PCR), to analyze the regulation and expression of these proteins in the serum, urine and tissues of OAB patients. Using statistical analyses, we compare the protein expressions between OAB patients and control subjects to identify the pathogenesis of OAB. In addition, in order to understand the therapeutic mechanism of onabotulinumtoxinA (BoNT-A) therapy, our laboratory also investigates the changes of bladder functional proteins in the tissue of patients before and after BoNT-A treatment.

The results of our current study indicated the following: (1) increased numbers of mast cells in the bladder and elevated levels of serum and urinary NGF and pro-inflammation proteins, which suggested involvement of local or systemic inflammation in certain OAB patients; (2) elevation of P2X3 and PGP9.5 expressions in the bladder mucosa of patients refractory to antimuscarinic drugs, which implied that an abnormally increased level of the sensory receptor P2X3 is one part of the pathogenesis of the disease.

In recent years, we found that oxidative stress caused by ischemia and reperfusion also plays an important role in several diseases. Therefore, future goals of our laboratory include the use of rat and transgenic mouse models to study the effects of oxidative stress on the bladder and other organs, and the application of antioxidant drugs in current clinical use for the treatment of other diseases to explore whether the drugs cause molecular pathological changes in the bladders of patients. By comparison with clinical specimens from patients, our study combined basic research and clinical pathologic analysis, and the findings provide an objective reference for clinicians regarding the diagnosis and treatment of diseases.

Publication (in five years)：

1.	Liu HT, Kuo HC: Expressions of urothelial functional proteins in idiopathic detrusor overactivity patients refractory to antimuscarinic therapy with different urodynamic characteristics. Neurourol Urodyn, 2016, Sep 21. doi: 10.1002/nau.23138. [Epub ahead of print].(SCI)
2.	Chuang FC, Liu HT, Kuo HC: Lower Levels of Urinary Nerve Growth Factor Might Predict Recurrent Urinary Tract Infections in Women. International Neurourology Journal, 2016, 20(1): 33-39.(SCI)
3.	Liu HT, Chen SH, Chancellor MB, Kuo HC: Presence of Cleaved Synaptosomal-Associated Protein-25 and Decrease of Purinergic Receptors P2X3 in the Bladder Urothelium Influence Efficacy of Botulinum Toxin Treatment for Overactive Bladder Syndrome. PLoS One, 2015, 4;10(8):e0134803. doi: 10.1371/journal.pone.0134803. (SCI)
4.	Liu HT, Kuo HC: Biomarkers for patients with interstitial cystitis/bladder pain syndrome. Urological Science, 2015, 26(4): 225-229. (Review)
5.	Liu HT, Jiang YH, Kuo HC: Alteration of Urothelial Inflammation, Apoptosis, and Junction Protein in Patients with Various Bladder Conditions and Storage Bladder Symptoms Suggest Common Pathway Involved in Underlying Pathophysiology. LUTS-Lower Urinary Tract Symptoms, 2015, 7(2): 102-107.(SCI)
6.	Jiang YH, Liu HT, Kuo HC: Urothelial dysfunction and chronic inflammation in patients with spinal cord injuries at different levels and correlation with urodynamic findings. Neurourol Urodyn, 2015, 34: 757-762.(SCI)
7.	Jiang YH, Liu HT, Kuo HC: Decrease of Urinary Nerve Growth Factor but Not Brain-Derived Neurotrophic Factor in Patients with Interstitial Cystitis/Bladder Pain Syndrome Treated with Hyaluronic Acid. PLoS One, 2014.9(3): p. e91609(SCI)
8.	Kuo HC, Liu HT,Chuang YC, Birder LA, Chancellor, MB: Pilot study of liposome-encapsulated onabotulinumtoxina for patients with overactive bladder: a single-center study. Eur Urol, 2014,65(6): 1117-1124(SCI)
9.	Chuang FC, Liu HT, Wang LY, Kuo HC: Overactive bladder changes with time: a 5-year longitudinal followup of changes in overactive bladder symptoms, urodynamic studies and urinary nerve growth factor levels. J Urol, 2014,192(2): 458-463.(SCI)
10.	Kuo HC , Liu HT, Shie JH: Potential urine and serum biomarkers for patients with overactive bladder and interstitial cystitis/bladder pain syndrome. Tzu Chi Medical Journal 2013; 25:13-18.
11.	Liu HT, Jiang YH, Kuo HC: Increased Serum Adipokines Implicate Chronic Inflammation in the Pathogenesis of Overactive Bladder Syndrome Refractory to Antimuscarinic Therapy. PLoS One, 2013;8(10): p. e76706(SCI)
12.	Jiang YH, Peng CH, Liu HT, Kuo HC: Increased Pro-Inflammatory Cytokines, C-Reactive Protein and Nerve Growth Factor Expressions in Serum of Patients with Interstitial Cystitis/Bladder Pain Syndrome. PLoS One, 2013;8(10): p. e76779(SCI)
13.	ChenYR, Huang HB, Lo CJ, Wang CC, Ho LK, Liu HT, Shiao MS, Lin DT, Chen YC: Effect of Alanine Replacement of L17 and F19 on the Aggregation and Neurotoxicity of Arctic-Type Ab40. PLoS One, 2013.8(4): p. e61874 (SCI)

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Dr. Pang, Cheng-Yoong

Dr. Wang, Mei-Jen

Dr. Yang, Hsueh-Hui

Dr. Liew, Hock-Kean

Dr. Liu, Hsin-Tzu

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