專利文章

Patent  Method for extraction lectin from Chaenomeles lagenaria, medical composition for inhibiting tumor growth, biological reagent for detecting glycophorin A on blood and blood typing kit
Classification  Invention PATENT
Patentee  YANG, KUO LIANG
Abstract  A Chaenomeles lagenaria extract having a lectin specific for glycophorin A and method for extracting the same are proposed. The extract is prepared by homogenizing seeds of Chaenomeles lagenaria with a homogenizing agent into a mixture, and the mixture is further processed to produce the extract both effective in inhibiting tumor growth and applicable to a blood typing test.

 

 

Patent Method for extracting antineoplastic components from Bupleurum scorzonerifolium
Classification Invention Patent
Patentee LIN, SHINN ZONG; HARN, HORNG JYH
Abstract A method for extracting antineoplastic component from Bupleurum scorzonerifolium applicable in treating cell proliferative disorder is proposed. The antineoplastic components of Bupleurum scorzonerifolium include at least a Y-butyolactone centred heterocyclic compound with a Z configuration or E configuration at its carbon 2(5) position, and molecules, such as Chaihulactone, Isochaihulactone, Chaihulactone analogues or derivatives containing in the heterocyclic compound. From results of cell and molecular biological studies, in vivo animal test, and histological study, it is found that antineoplastic components extracted from Bupleurum scorzonerifolium are effective in suppressing a variety of cancer cell growths, inhibiting telomerase activity, as well as effective in killing with high specificity Taxol-resistant tumor cells at later stage of chemical therapy, making the components a new choice for anti-cancer agent, anti-HIV agent, or synergistic agent.

 

 

Patent  γ-butyrolactone compound and pharmaceutical composition thereof
Classification  Invention
Patentee  LIN, SHINN ZONG; HARN, HORNG JYH
Abstract  A γ-butyrolactone compound as shown in Formula (I) and pharmaceutical composition thereof:wherein X═N, O, S, Se; and A and B are selected from substituents having the following formula:wherein R1, R2, R3, R4, and R5 are selected from a hydrogen atom, a halogen atom, a hydroxyl group, a mercapto group, an amino group, an alkoxy group, and a nitro group. The γ-butyrolactone compound and pharmaceutical composition thereof butyrolactone have inhibitory effects on hepatoma, ovarian cancer, breast cancer, lung cancer, malignant glioblastoma or colorectal carcinoma, and are cytotoxic with high specificity to inhibit Paclitaxel-resistant tumor cells at later stage of chemotherapy without any damage on normal cells.

 

 

 

 

Patent  Method for screening compounds against Flaviviruses by using persistent virus-infected cell system
Classification  Invention PATENT
Patentee  CHEN, LI KUANG
Abstract  This invention provides a method for screening compounds against Flavivirus. More specifically, this invention provides a method for screening compounds against Flaviviruses by using a persistent virus-infected cell system, including (a) establishment of persistent virus-infected cell lines, (b) preparation of monoclonal antibody by using said persistent virus-infected cell lines, (c) incubation of tested compounds with said persistent virus-infected cell lines, (d) determination of the inhibition effect of tested compounds or vaccines on Flavivirus by sandwich ELISA using said monoclonal antibody.

 

 

Patent  Angelicae sinensis extracts useful for treatment of cancers
Classification  Invention PATENT
Patentee  HARN, HORNG-JYH ;CHANG, WEN-LIANG ; LIN, SHINN-ZONG
Abstract  The invention provides an acetone extract, chloroform extract or hexane extract of Angelicae sinensis and/or the active components purified therefrom, such as n-butylidenephthalide, which are effective in treating cancers.

 

 

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