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Dr. Liew, Hock-Kean | |
| E-mail：Email住址會使用灌水程式保護機制。你需要啟動Javascript才能觀看它 | ||
| Ext：15911 | ||
| National Defense Medical College, Taiwan. Ph.D. | ||
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Expertise：System Biology, Neuroscience,Biomaterial & Scaffold, Brain Injury |
Interest：
| Ischemic stroke is a major cause of morbidity and mortality worldwide. To date, no effective treatment is available to reverse the brain damage due to the difficulty to regenerate the matured neuron lost. Over the past few years, though the brain injury platform that we created (cerebral ischemic and cerebral hemorrhagic model), we are trying to establish new drugs and methods to reduce the neurological injury after brain injury. We demonstrated that G-CSF, urocortin and the Neural progenitor cells (NPCs) might possess beneficial effects against brain injury. Recently, our study focus on the combination of urocortin and the NPCs to treat cerebral ischemia. NPCs are considered the ultimate lineage precursors to all neuronal and glial cells. Because of their ability to self-renew, NPCs have promise for treatment of neurological diseases by transplantation therapy, and has been shown to promote recovery of neuronal functions after stroke. However, the disruption of the tissue architecture after brain injury limits the transplant efficacy. Besides, only a small proportion of grafted cells survived in the ischemic brain and rare differentiation to mature neurons. This massive loss of stem cells and rare differentiation to mature neurons post-engraftment is an impediment that lessens the effectiveness of cell transplantation therapy. Urocortin (UCN), a 40 amino acid peptide, which was first identified in rat midbrain. The function of this neuropeptide is to regulate neuroendocrine, autonomic, and immunologic responses to stress. Our results showed that, preconditioning with UCN conferred cytoprotection on NPCs and promoted their differentiation in an in vitro ischemia/reperfusion model. Therefore, we intended to clarify the role of UCN in modulating the NPCs survival, differentiation and the therapeutic efficacy of transplanted NPCs after chronic cerebral I/R injury. This study will provide a new insight into the potential of UCN by increasing survival and neuronal differentiation of transplanted NPCs, to repair the adult brain after chronic ischemic stroke in the future. |
Publication (in five years)：
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1. |
Moderate Ethanol Pre-treatment Mitigates ICH-Induced Injury via ER Stress Modulation in Rats. |
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2. |
A Role for Endoplasmic Reticulum Stress in Intracerebral Hemorrhage. |
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3. |
The Role of Urocortins in Intracerebral Hemorrhage. |
| 4. |
Harnessing Neurogenesis and Neuroplasticity with Stem Cell Treatment for Addictive Disorders. |
| 5. |
Over-Activated Proteasome Mediates Neuroinflammation on Acute Intracerebral Hemorrhage in Rats. |
| 6. |
Brain Magnetic Resonance Imaging of Intracerebral Hemorrhagic Rats after Alcohol Consumption. |
| 7. |
Delayed formation of hematomas with ethanol preconditioning in experimental intracerebral hemorrhage rats. |
| 8. |
Collagenase-Induced Rat Intra-Striatal Hemorrhage Mimicking Severe Human Intra-Striatal Hemorrhage. |
