本研究室主要研究發炎反應與基因突變造成巴金森氏症之致病機轉，尿皮質素對於神經細胞分化與保護之探討及神經細胞與微膠細胞間之交互作用。研究方向包括：

1.微膠細胞在神經退化性疾病所扮演角色之研究

2.巴金森氏症Parkin基因突變對神經細胞抗氧化、神經毒素、發炎反應等壓力之研究

3.尿皮質素對於神經細胞神經保護，神經新生及抗發炎反應之研究

4.神經細胞外泌體調控微膠細胞活化之研究

Our current interests focus on:

1. The role of microglia (an immune cell in the brain) in the neurodegenerative diseases, such as Parkinson’s disease.

2. The effect of Parkin gene mutation in dopaminergic neurons exposed to oxidative stress, neurotoxins and inflammation.

3. The function of neuropeptide, urocortin, on neuroprotection, neuronal differentiation of neural stem cells and anti-inflammation.

4. Regulation of neuron-derived exosomes on microglial activation.

1.

Huang HY, Chang HF, Tsai MJ, Chen JS, Wang MJ* (2016) 6-Mercaptopurine attenuates tumor necrosis factor-a production in microglia through Nur77-mediated transrepression and PI3K/Akt/mTOR signaling-mediated translational regulation. J Neuroinflammation 13:78. (*corresponding author).

2.

Chou YC, Chang MY, Wang MJ, Liu HC, Chang SJ, Harnod T, Hung CH, Lee HT, Shen CC, Chung JG (2015) Phenethyl isothiocyanate alters the gene expression and the levels of protein associated with cell cycle regulation in human glioblastoma GBM8401 cells. Environ Toxicol DOI: 10.1002/tox.22224.

3.

Chou YC, Chang MY, Wang MJ, Yu FS, Liu HC, Harnod T, Hung CH, Lee HT, Chung JG (2015) PEITC inhibits human brain glioblastoma GBM8401 cell migration and invasion through the inhibition of uPA, RhoA, and Ras with inhibition of MMP-2, -7 and -9 gene expression. Oncol Rep 34:2489-2496.

Huang HY, Chiu TL, Chang HF, Hsu HR, Pang CY, Liew HK, Wang MJ* (2015) Epigenetic regulation contributes to urocortin-enhanced midbrain dopaminergic neuron differentiation. Stem Cells 33:1601-1617. (*corresponding author).

Chou YC, Chang MY, Wang MJ, Harnod T, Huang CH, Lee HT, Shen CC, Chung JG (2015) PEITC induces apoptosis of human brain glioblastoma GBM8401 cells through the extrinsic- and intrinsic-signaling pathways. Neurochem Int 81:32-40.

Tsai MJ, Yang-Yen HF, Chiang MK, Wang MJ, Wu SS, Chen SH (2014) TCTP is essential for b-cell proliferation and mass expansion during development and b-cell adaptation in response to insulin resistance. Endocrinology 155: 392-404.

Huang HY, Liu DD, Chang HF, Chen WF, Hsu HR, Kuo JS, Wang MJ* (2012) Histone deacetylase inhibition mediates urocortin-induced antiproliferation and neuronal differentiation in neural stem cells. Stem Cells 30: 2760-2773. (*corresponding author).

Chiu TL, Wang MJ, Su CC (2012) The treatment of glioblastoma multiforme through activation of microglia and TRAIL induced by rAAV2-mediated IL-12 in a syngeneic rat model. J Biomed Sci 19:45

Chiu SC, Chen SP, Huang SY, Wang MJ, Lin SZ, Harn HJ, Pang CY (2012) Induction of apoptosis coupled to endoplasmic reticulum stress in human prostate cancer cells by n-butylidenephthalide. PLoS ONE 7: e33742

Liew HK, Pang CY, Hsu CW, Wang MJ, Li TY, Peng HF, Kuo JS, Wang JY (2012) Systemic administration of urocortin after intracerebral hemorrhange reduces neurological deficits and neuroinflammation in rats. J Neuroinflammation 9:13

Liew HK, Hsu CW, Wang MJ, Kuo JS, Li TY, Peng HF, Wang JY, Pang CY (2012) Therapeutic benefit of urocortin in rats with intracerebral hemorrhage. J. Neurosurg. 116: 193-200.