醫師代號 : 45005
專 長
●學術專長：分子醫學、病理學、腫瘤生物學、急診醫學
●研究方向：中藥、新藥開發、抗癌、抗老化、分子診斷基因檢測
現 職
- 慈濟醫院解剖病理部分子病理科主任
- 慈濟醫院解剖病理部主治醫師
- 慈濟醫療財團法人創新研發中心 副研發長
學 歷
- 國防醫學院 醫學系
- 美國杜克大學 病理學博士
經 歷
1.三軍總醫院外科病理科 主任
2.三軍總醫院病理部 主治醫師
3.三軍總醫院急診部 主治醫師
4.花蓮慈濟醫院急診部 主治醫師
5.花蓮慈濟醫院病理部 主治醫師
6.中國醫藥大學附設醫院病理部 主任
7.中國醫藥大學附設醫院病理部 主治醫師
榮譽
- 榮獲2023年花蓮慈院績優技轉獎
- 榮獲2023年國家新創獎之國家新創精進獎：HK-001-Wafer對抗人類惡性腦膠質瘤(GBM)
- 榮獲2022年國家新創獎之臨床新創獎：Cerebraca wafer治療經標準治療無效復發性惡性腦瘤
- 榮獲2021年國家新創獎之學研新創獎：定點緩釋給藥-開發治療胰臟癌新藥EF-009
- 榮獲2021年國家新創獎之精進續獎：HK-001-Wafer對抗人類惡性腦膠質瘤(GBM)
- 榮獲2021年國家新創獎之精進續獎：HK-001用於治療肌萎縮側索硬化(ALS)之開發計畫
- 榮獲2020年國家新創獎之學研新創獎：靶向Sox2的小分子LF-001應用於肺纖維化的治療
- 榮獲2019年三項國家新創獎：漸凍症、惡性腦瘤新藥以及癌症免疫療法
- 獲表揚為2018年美國國家發明家學會(National Academy of Inventors，NAI)新科院士
- 榮獲2017年以漸凍症新藥開發和iPS神經分化技術兩項國家新創獎
期刊論文
1. Chen-Tran Hsu, Chi-Chou Chiu, Pao-Yuan Hsiao, Chih-Yu Lin, Sychyi Cheng,
Yao-Cheng Lin, Yu-Liang Yang, Fu-Hui Wu, Horng-Jyh Harn, Shinn-Zong Lin,
Choun-Sea Lin (2024, Jan). Transgene-free CRISPR/Cas9-mediated gene editing
through protoplast-to-plant regeneration enhances active compounds in Salvia
miltiorrhiza. Plant Biotechnology Journal. 本人為通訊作者.
2. Tsung-Yun Wu, Chun-Chiang Huang, Hsieh-Chih Tsai, Tzu-Kai Lin, Pei-Yu
Chen, Haile Fentahun Darge, Zhen-Xiang Hong, Horng-Jyh Harn, Shinn-Zong
Lin, Juin-Yih Lai, Yu-Shuan Chen (2024, Jan). Mucin-mediated mucosal
retention via end-terminal modified Pluronic F127-based hydrogel to increase
drug accumulation in the lungs. Biomaterials Advances.
3. Yu-Shuan Chen, Zhen-Xiang Hong, Yi-Tung Lin, En-Ci Tsao, Pei-Yu Chen,
Ching-Ann Liu, Horng-Jyh Harn, Tzyy-Wen Chiou, Shinn-Zong Lin (2023,
Dec). Efficiency of PGK1 proteins delivered to the brain via a liposomal system
through intranasal route administration for the treatment of spinocerebellar ataxia
type 3. Drug Delivery and Translational Research.
4. Yu-Shuan Chen, Horng-Jyh Harn, Zhen-Xiang Hong, Yi-Chen Huang, Yi-Tung
Lin, Hui-Xuan Zheng, Pei-Yu Chen, Hsueh-Hui Yang, Peir-Rong Chen, Hsieh-
Chih Tsai, Shinn-Zong Lin, Tsung-Jung Ho, Tzyy-Wen Chiou (2023, Nov).
Preconditioning of exosomes derived from human olfactory ensheathing cells
improved motor coordination and balance in an SCA3/MJD mouse model: A
new therapeutic approach. European Journal of Pharmaceutical Sciences,
191:106608.
5. Hsiao-Chien Ting, Hong-Lin Su, Mei-Fang Chen, Horng-Jyh Harn, Shinn-Zong
Lin, Tzyy-Wen Chiou, Chia-Yu Chang (2022, Nov). Robust Generation of
Ready-to-Use Cryopreserved Motor Neurons from Human Pluripotent Stem
Cells for Disease Modeling. International Journal of Molecular Sciences,
23(21):13462..
6. Shih-Fang Wu, Chih-Yao Lin, Rong-Kung Tsai, Yao-Tseng Wen, Feng-Huei Lin,
Chia-Yu Chang, Ching-I Shen, Shinn-Zong Lin, Horng-Jyh Harn, Tzyy-Wen
Chiou, Chin-San Liu, Yan-Ting Chen, and Hong-Lin Su (2022, Nov).
Mitochondrial Transplantation Moderately Ameliorates Retinal Degeneration in Royal College of Surgeons Rats. Biomedicines, 10(11): 2883.
7. Wei Wuli, Shinn-Zong Lin, Shee-Ping Chen, Bakhos A. Tannous, Wen-Sheng
Huang, Peng Yeong Woon, Yang-Chang Wu, Hsueh-Hui Yang, Yi-Cheng Chen,
Renata Lopes Fleming, Jack T. Rogers, Catherine M. Cahill, Tsung-Jung Ho,
Tzyy-Wen Chiou, and Horng-Jyh Harn (2022, Sep). Targeting PSEN1 by lnc-
CYP3A43-2/miR-29b-2-5p to Reduce β Amyloid Plaque Formation and Improve
Cognition Function. International Journal of Molecular Sciences, 23(18):
10554.. 本人為通訊作者.
8. Ching-Ann Liu, Horng-Jyh Harn, Kuan-Pin Chen, Jui-Hao Lee, Shinn-Zong Lin,
and Tsung-Lang Chiu (2022, May). Targeting the Axl and mTOR Pathway
Synergizes Immunotherapy and Chemotherapy to Butylidenephthalide in a
Recurrent GBM. Journal of Oncology, 2022:3236058. .
9. Pei-Yin Chen, Shih-Chi Chao, Pei-Ling Hsieh, Yi-Wen Liao, Pei-Ming Chu,
Horng-Jyh Harn, and Cheng-Chia Yu (2022, May). Butylidenephthalide
Abrogates the Snail-Induced Cancer Stemness in Oral Carcinomas. International
Journal of Molecular Sciences, 23(11): 6157.. 本人為通訊作者.
10. Tefera Worku Mekonnen, Haile Fentahun Darge, Hsieh-Chih Tsai, Yihenew
Simegniew Birhan, Endiries Yibru Hanurry, Hailemichael Tegenu Gebrie, Hsiao-
Ying Chou, Juin-Yih Lai, Shinn-Zong Lin, Horng-Jyh Harn, Yu-Shuan Chen
(2022, May). Combination of ovalbumin-coated iron oxide nanoparticles and
poly(amidoamine) dendrimer-cisplatin nanocomplex for enhanced anticancer
efficacy. Colloids and Surfaces B: Biointerfaces , 213:112391..
11. Ching-Ann Liu, Wei-Hsiu Liu, Hsin-I Ma, Yuan-Hao Chen, Dueng-Yuan Hueng,
Wen-Chiuan Tsai, Shinn-Zong Lin, Horng-Jyh Harn, Tzyy-Wen Chiou, Jen-Wei
Liu, Jui-Hao Lee, Tsung-Lang Chiu (2022, Feb). Interstitial Control-Released
Polymer Carrying a Targeting Small-Molecule Drug Reduces PD-L1 and MGMT
Expression in Recurrent High-Grade Gliomas with TMZ Resistance. Cancers
(Basel). , 14(4): 1051..
12. Hsin-Han Yang, I-Tsang Chiang, Jen-Wei Liu, Jeanne Hsieh, Jui-Hao Lee, Huai-
En Lu, Hwa-Sung Tso, Yu-Chen Deng, Jo-Chi Kao, Jhen-Rong Wu, Horng-Jyh
Harn, and Tzyy-Wen Chiou (2022, Jan). Anti-Excitotoxic Effects of N-
Butylidenephthalide Revealed by Chemically Insulted Purkinje Progenitor Cells
Derived from SCA3 iPSCs. International Journal of Molecular Sciences ,
23(3):1391.. 本人為通訊作者.
13. Tsung‐Lang Chiu, Rathinasamy Baskaran, Sheng‐Tzung Tsai, Chih‐Yang Huang,
Ming‐Hsi Chuang, Wan‐Sin Syu, Horng‐Jyh Harn, Yi‐Chun Lin, Chun‐Hung
Chen, Pi‐Chun Huang, Yi‐Fen Wang, Chi‐Hsuan Chuang, Po‐Cheng Lin, Shinn‐
Zong Lin (2022, Jan). Intracerebral transplantation of autologous adipose‐derived stem cells for chronic ischemic stroke: A phase I study. Journal of tissue
engineering and regenerative medicine, 16:3-13.
https://doi.org/10.1002/term.3256.
14. Hueng-Chuen Fan,Fung-Wei Chang, Jeng-Dau Tsai, Kao-Min Lin, Chuan-Mu
Chen, Shinn-Zong Lin, Ching-Ann Liu, and Horng-Jyh Harn (2021, Dec).
Telomeres and Cancer. Life (Basel)., 11(12): 1405.. 本人為通訊作者.
15. Kang-Yun Lu , Kingsley Theras Primus Dass , Shinn-Zong Lin, Yu-Hua Tseng ,
Shih-Ping Liu , Horng-Jyh Harn (2021, Dec). n-butylidenephthalide ameliorates
high-fat diet-induced obesity in mice and promotes browning through adrenergic
response/AMPK activation in mouse beige adipocytes. Biochim Biophys Acta
Mol Cell Biol Lipids., 1866(12):159033. 本人為通訊作者.
16. Tsung-Ming Lee, Cheng-Che Lee, Horng-Jyh Harn, Tzyy-Wen Chiou, Ming-Hsi
Chuang, Chun-Hung Chen, Chi-Hsuan Chuang, Po-Cheng Lin, Shinn-Zong Lin
(2021, Dec). Intramyocardial injection of human adipose-derived stem cells
ameliorates cognitive deficit by regulating oxidative stress-mediated
hippocampal damage after myocardial infarction. Journal of Molecular
Medicine, 1815-1827. .
17. Hsiao-Chien Ting, Hui-I Yang, Horng-Jyh Harn, Ing-Ming Chiu, Hong-Lin Su,
Xiang Li, Mei-Fang Chen, Tsung-Jung Ho, Ching-Ann Liu, Yung-Jen Tsai,
Tzyy-Wen Chiou, Shinn-Zong Lin, and Chia-Yu Chang (2021, Oct).
Coactivation of GSK3β and IGF-1 Attenuates Amyotrophic Lateral Sclerosis
Nerve Fiber Cytopathies in SOD1 Mutant Patient-Derived Motor Neurons.
Cells., 10(10):2773. .
18. Hsin-Han Yang, Jen-Wei Liu, Jui-Hao Lee, Horng-Jyh Harn, and Tzyy-Wen
Chiou (2021, Jul). Pancreatic Adenocarcinoma Therapeutics Targeting RTK and
TGF Beta Receptor. International Journal of Molecular Sciences, 22(15): 8125..
本人為通訊作者.
19. Kang-Yun Lu , Shinn-Zong Lin, Kingsley Theras Primus Dass , Wei-Ju Lin ,
Shih-Ping Liu , Horng-Jyh Harn (2021, Jul). 3-N-butylphthalide protects against
high-fat-diet-induced obesity in C57BL/6 mice and increases metabolism in
lipid-accumulating cells. Biomed Pharmacother., 139:111687. 本人為通訊作者.
20. Jui-Hao Lee, Si-Yin Lin, Jen-Wei Liu, Shinn-Zong Lin, Horng-Jyh Harn, and
Tzyy-Wen Chiou (2021, Jun). n-Butylidenephthalide Modulates Autophagy to
Ameliorate Neuropathological Progress of Spinocerebellar Ataxia Type 3
through mTOR Pathway. International Journal of Molecular Sciences,
22(12):6339.. 本人為通訊作者.
21. Wei WuLi, Horng-Jyh Harn, Tzyy-Wen Chiou, and Shinn-Zong Lin (2021, Feb).
Chinese herbs and acupuncture to improve cognitive function in Alzheimer's disease. Tzu Chi Medical Journal, 33(2):122-127..
22. Hong-Meng Chuang, Li-Ing Ho, Horng-Jyh Harn, and Ching-Ann Liu (2021,
Jan). Recent Findings on Cell-Based Therapies for COVID19-Related
Pulmonary Fibrosis. Cell Transplantation, 30:963689721996217..
23. Hsin-Han Yang, Yue-Xuan Xu, Jie-Yi Chen, Horng-Jyh Harn, Tzyy-Wen Chiou
(2020, Oct). N-Butylidenephthalide Inhibits the Phenotypic Switch of VSMCs
through Activation of AMPK and Prevents Stenosis in an Arteriovenous Fistula
Rat Model. Int J Mol Sci, 21(19):7403.
24. Kang-Yun Lu, Kingsley Theras Primus Dass, Shinn-Zong Lin, Horng-Jyh Harn,
Shih-Ping Liu (2020, Oct). The application of stem cell therapy and brown
adipose tissue transplantation in metabolic disorders. Cytotherapy, 22(10):521-
528. 本人為通訊作者.
25. En-Yi Lin, Yu-Shuan Chen, Yuan-Sheng Li, Syuan-Rong Chen, Chia-Hung Lee,
Mao-Hsuan Huang, Hong-Meng Chuang, Horng-Jyh Harn, Hsueh-Hui Yang,
Shinn-Zong Lin, Dar-Fu Tai, Tzyy-Wen Chiou (2020, Jun). Liposome
Consolidated with Cyclodextrin Provides Prolonged Drug Retention Resulting in
Increased Drug Bioavailability in Brain. Int J Mol Sci, 21(12):4408.
26. Chia-Yu Chang, Hsiao-Chien Ting, Ching-Ann Liu, Hong-Lin Su, Tzyy-Wen
Chiou, Shinn-Zong Lin, Horng-Jyh Harn, Tsung-Jung Ho (2020, Apr). Induced
Pluripotent Stem Cell (iPSC)-Based Neurodegenerative Disease Models for
Phenotype Recapitulation and Drug Screening. Molecules, 25(8):2000.
27. Yu-Shuan Chen, Zhen-Xiang Hong, Shinn-Zong Lin, Horng-Jyh Harn (2020,
Apr). Identifying Therapeutic Targets for Spinocerebellar Ataxia Type
3/Machado-Joseph Disease through Integration of Pathological Biomarkers and
Therapeutic Strategies. Int J Mol Sci., 21(9):3063.. 本人為通訊作者.
28. Wei Wuli, Sheng-Tzung Tsai, Tzyy-Wen Chiou, Horng-Jyh Harn (2020, Feb).
Human-Induced Pluripotent Stem Cells and Herbal Small-Molecule Drugs for
Treatment of Alzheimer's Disease. Int J Mol Sci., doi: 10.3390/ijms21041327..
本人為通訊作者.
29. Hong-Meng Chuang, Mao-Hsuan Huang, Yu-Shuan Chen, Horng-Jyh Harn
(2020, Jan). SOX2 for Stem Cell Therapy and Medical Use: Pros or Cons?. Cell
Transplant, doi: 10.1177/0963689720907565.. 本人為通訊作者.
30. Kang-Yun Lu, Kingsley Theras Primus Dass, Sheng-Feng Tsai, Hong-Meng
Chuang, Shinn-Zong Lin, Shih-Ping Liu, Horng-Jyh Harn (2020, Jan). Clinical
Application Potential of Small Molecules that Induce Brown Adipose Tissue
Thermogenesis by Improving Fat Metabolism. Cell Transplant., doi:
10.1177/0963689720927394.. 本人為通訊作者.
