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專 長

• 神經科學
• 病毒學
• 胚胎幹細胞

現 職

• 創新研發中心 顧問
• 國立中興大學生命科學系 教授

學 歷

• 國防醫學院 生命科學研究所 博士

經 歷

• 日本理化學研究所發生‧再生科學總合研究中心訪問研究員
• 日本財團法人先端醫療振興財團主任研究員
• 國立中興大學 生命科學系 教授

研 究 方 向

• 研究興趣

1. 遺傳性與退化性神經疾病之細胞模式的建立
2. 由胚胎幹細胞分化成為特定的神經細胞，如多巴胺神經細胞與運動神經細胞
3. 體外粒線體的遞送與治療

• 研究主題

1. 胚幹細胞的神經分化
2. 阿茲海默症的藥物開發
3. 粒線體遞送與疾病治療

• 目前研究計畫

1. 科技部 以粒線體遞送治療不孕症
2. 教育部 邁頂計畫 動物疫苗

著 作

• Chang, J.C., S.L. Wu, K.H. Liu, Y.H. Chen, C.S. Chuang, F.C. Cheng, H.L. Su, Y.H. Wei, S.J. Kuo, and C.S. Liu, 2016 Allogeneic/xenogeneic transplantation of peptide-labeled mitochondria in Parkinson's disease: restoration of mitochondria functions and attenuation of 6-hydroxydopamine-induced neurotoxicity.,Transl Res,. vol.170, pp.40-56. (SCI)
• Chen, Y.H., C.C. Chung, Y.C. Liu, S.P. Yeh, J.L. Hsu, M.C. Hung, H.L. Su, and L.Y. Li, 2016 Enhancer of Zeste Homolog 2 and Histone Deacetylase 9c Regulate Age-Dependent Mesenchymal Stem Cell Differentiation into Osteoblasts and Adipocytes. ,Stem Cells. vol.34, no.8, pp.2183-93.. (SCI)
• Chiang, C.Y., S.A. Liu, M.L. Sheu, F.C. Chen, C.J. Chen, H.L. Su, and H.C. Pan 2016 Feasibility of Human Amniotic Fluid Derived Stem Cells in Alleviation of Neuropathic Pain in Chronic Constrictive Injury Nerve Model,PLoS One. vol.11, no.7, pp.e0159482.. (SCI)
• Chuang, C.S., H.L. Su, C.L. Lin, and C.H. Kao 2016 Risk of Parkinson disease after organophosphate or carbamate poisoning,Acta Neurol Scand, . (SCI)
• Chuang, H.M., H.L. Su, C. Li, S.Z. Lin, S.Y. Yen, M.H. Huang, L.I. Ho, T.W. Chiou, and H.J. Harn, 2016 The Role of Butylidenephthalide in Targeting the Microenvironment Which Contributes to Liver Fibrosis Amelioration. ,Front Pharmacol, . vol.7, pp.112.
• Huang, P.J., C.C. Kuo, H.C. Lee, C.I. Shen, F.C. Cheng, S.F. Wu, J.C. Chang, H.C. Pan, S.Z. Lin, C.S. Liu, and H.L. Su 2016 Transferring Xenogenic Mitochondria Provides Neural Protection Against Ischemic Stress in Ischemic Rat Brains. ,Cell Transplant.. vol.25, no.5, pp.913-27.. (SCI)
• Lu, Y.C., M.L. Lin, H.L. Su, and S.S. Chen, 2016 ER-Dependent Ca++-mediated Cytosolic ROS as an Effector for Induction of Mitochondrial Apoptotic and ATM-JNK Signal Pathways in Gallic Acid-treated Human Oral Cancer Cells.,Anticancer Res. vol.36, no.2, pp.697-705.. (SCI)
• Or, C.R., H.L. Su, W.C. Lee, S.Y. Yang, C. Ho, and C.C. Chang, 2016 Diphenhydramine induces melanoma cell apoptosis by suppressing STAT3/MCL-1 survival signaling and retards B16-F10 melanoma growth in vivo,Oncol. Rep. (SCI)
• Pai, C.L., Y.C. Chen, C.Y. Hsu, H.L. Su, and P.S. Lai 2016 Carbon Nanotube-Mediated Photothermal Disruption of Endosomes/Lysosomes Reverses Doxorubicin Resistance in MCF-7/ADR Cells,J Biomed Nanotechnol, . vol.12, no.4, pp.619-29.. (SCI)Chang, C.Y., S.M. Chen, H.E. Lu, S.M. Lai, P.S. Lai, P.W. Shen, P.Y. Chen, C.I. Shen, H.J. Harn, S.Z. Lin, S.M. Hwang, and H.L. Su, 2015 N-butylidenephthalide attenuates Alzheimer's disease-like cytopathy in Down syndrome induced pluripotent stem cell-derived neurons,Sci Rep.. vol.5, pp.8744. (SCI)
• Chang, C.Y., S.M. Chen, H.E. Lu, S.M. Lai, P.S. Lai, P.W. Shen, P.Y. Chen, C.I. Shen, H.J. Harn, S.Z. Lin, S.M. Hwang, and H.L. Su, 2015 N-butylidenephthalide attenuates Alzheimer's disease-like cytopathy in Down syndrome induced pluripotent stem cell-derived neurons,Sci Rep.. vol.5, pp.8744. (SCI)
• Chang, Y.J., H.L. Su, L.F. Hsu, P.J. Huang, T.H. Wang, F.C. Cheng, L.W. Hsu, M.S. Tsai, C.P. Chen, Y.L. Chang, A.S. Chao, and S.M. Hwang, 2015 Isolation of Human Neural Stem Cells from the Amniotic Fluid with Diagnosed Neural Tube Defects.,Stem Cells Dev.. vol.24, no.15, pp.1740-50.. (SCI)
• Chen, C.J., F.C. Cheng, H.L. Su, M.L. Sheu, Z.H. Lu, C.Y. Chiang, D.Y. Yang, J. Sheehan, and H.C. Pan 2015 Improved neurological outcome by intramuscular injection of human amniotic fluid derived stem cells in a muscle denervation model. ,PLoS One. vol.10, no.5, pp.e0124624. (SCI)
• Chen, S.M., M.S. Lee, C.Y. Chang, S.Z. Lin, E.H. Cheng, Y.H. Liu, H.C. Pan, H.C. Lee, and H.L. Su 2015 Prerequisite OCT4 Maintenance Potentiates the Neural Induction of Differentiating Human Embryonic Stem Cells and Induced Pluripotent Stem Cells. ,Cell Transplant.. vol.24, no.5, pp.829-44..
• Lai, C.K., J.C. Su, Y.H. Lin, C.S. Chang, C.L. Feng, H.J. Lin, C.J. Lin, G.C. Tseng, H.H. Liu, J.T. Hsieh, H.L. Su, and C.H. Lai 2015 Involvement of cholesterol in Campylobacter jejuni cytolethal distending toxin-induced pathogenesis. ,Future Microbiol.. vol.10, no.4, pp.489-501.. (SCI)
• Sun, C.K., F.Y. Lee, Y.H. Kao, H.J. Chiang, P.H. Sung, T.H. Tsai, Y.C. Lin, S. Leu, Y.C. Wu, H.I. Lu, Y.L. Chen, S.Y. Chung, H.L. Su*, and H.K. Yip* 2015 Systemic combined melatonin-mitochondria treatment improves acute respiratory distress syndrome in the rat. ,J. Pineal Res.. vol.58, no.2, pp.137-50.. (SCI)
• Systemic combined melatonin-mitochondria treatment improves acute respiratory distress syndrome in the rat. 2015 Galangin Prevents Acute Hepatorenal Toxicity in Novel Propacetamol-Induced Acetaminophen-Overdosed Mice.,J. Med Food. vol.18, no.11, pp.1187-97.. (SCI)