Publications

2022-present

Miller N.R., Tsai RK. Optic Neuropathies: Current and Future Strategies for Optic Nerve Protection and Repair. International Journal of Molecular Sciences. 2023; 10;24(8):6977. View full text
Lin HD , Lee YC , Chiang CY , Lin YJ , Shih CY , Tsai RK , Lin PY , Lin SZ , Ho TJ , Huang CY. Protective effects of Scoparia dulcis L. extract on high glucose-induced injury in human retinal pigment epithelial cells. Frontiers in Nutrition. 2023; 30;10:1085248. View full text
Chen YH, Huang YC, Chen CH, Wen YT, Tsai RK, Chen CC. Investigation of the Protective Effect of Extracellular Vesicle miR-124 on Retinal Ganglion Cells Using a Photolabile Paper-Based Chip. Investigative Ophthalmology and Visual Science. 2023; 3;64(1):17. View full text
Hsu hL, Wen YT, Hsu TC, Chen CC, Lee LY, Chen WP, Tsai RK. Neuroprotective Effects of Erinacine A on an Experimental Model of Traumatic Optic Neuropathy. International Journal of Molecular Sciences. 2023;12;24(2):1504. View full text
Chen TW, Wu PY, Wen YT, Desai TD, Huang CT, Liu PK, Tsai RK. Vitamin B3 Provides Neuroprotection via Antioxidative Stress in a Rat Model of Anterior Ischemic Optic Neuropathy. Antioxidants. 2022; 8;11(12):2422. View full text
Sun MH, Chen KJ , Sun CC, Tsai RK. Protective Effect of Pioglitazone on Retinal Ganglion Cells in an Experimental Mouse Model of Ischemic Optic Neuropathy. International Journal of Molecular Sciences. 2022; 27;24(1):411. View full text
Wu SF, Lin CY, Tsai RK, Wen YT, Lin FH, Chang CY, Shen CI, Lin SZ, Harn HJ, Chiou TW, Liu CS, Chen YT, Su HL. Mitochondrial Transplantation Moderately Ameliorates Retinal Degeneration in Royal College of Surgeons Rats. Biomedicines. 2022; 10;10(11):2883. View full text
Huang TL, Wang JK , Chang PY, Hsu YR, Lin CH, Lin KH, Tsai RK. Neuromyelitis Optica Spectrum Disorder: From Basic Research to Clinical Perspectives. International Journal of Molecular Sciences. 2022; 18;23(14):7908. View full text
Tsai RK , Lin KL , Huang CT, Wen YT. Transcriptomic Analysis Reveals That Granulocyte Colony-Stimulating Factor Trigger a Novel Signaling Pathway (TAF9-P53-TRIAP1-CASP3) to Protect Retinal Ganglion Cells after Ischemic Optic Neuropathy. International Journal of Molecular Sciences. 2022; 28;23(15):8359. View full text
Liu PK, Chang YC, Wang NK, Ryu J, Tsai RK, Hsu SL, Hung JY, Hsu CY, Tai MH, Tsai MJ. The association between cataract and sleep apnea: a nationwide population-based cohort study. Journal of Clinical Sleep Medicine. 2022;1;18(3):769-777. View full text
Wen YT, Jhou BY, Hsu JH, Fu HI, Chen YL, Shih YC, Chen CC, Tsai RK. Neuroprotective Effects of Cordyceps cicadae (Ascomycetes) Mycelium Extract in the Rat Model of Optic Nerve Crush. International Journal of Medicinal Mushrooms. 2022;24(2):41-48. View full text
Chang YH, Kumar VB, Wen YT, Huang CY, Tsai RK, Ding DC. Induction of Human Umbilical Mesenchymal Stem Cell Differentiation Into Retinal Pigment Epithelial Cells Using a Transwell-Based Co-culture System. Cell Transplantation. 2022;31:9636897221085901. View full text
Desai TD ,Wen YT, Daddam JR, Cheng F, Chen CC, Pan CL, Lin KL, Tsai RK. Long term therapeutic effects of icariin-loaded PLGA microspheres in an experimental model of optic nerve ischemia via modulation of CEBP-β/G-CSF/noncanonical NF-κB axis. Bioengineering & Translational Medicine. 2022; 7;7(2):e10289. View full text

2011-2021

Huang CT, Wen YT, Desai TD, Tsai RK. Intravitreal injection of Long-acting pegylated granulocyte colony-stimulating factor provides neuroprotective effects via antioxidant responses in a rat model of traumatic optic neuropathy. Antioxidants. 2021;1;10(12):1934. View full text
Kang EY, Liu PK,Wen YT, Quin PMJ, Levi SR, Wang NK, Tsai RK. Role of oxidative stress in ocular diseases associated with retinal ganglion cells degeneration. Antioxidants . 2021;5;10(12):1948. View full text
Wen YT, Huang CW, Liu CP, Chen CH, Tu CM, Hwang CS , Chen YH, Chen WR, Lin KL, Ho YC, Chen TC, Tsai RK. Inhibition of Retinal Ganglion Cell Loss By a Novel ROCK Inhibitor (E212) in Ischemic Optic NerveInjury Via Antioxidative and Anti-Inflammator yActions. Investigative Ophthalmology and Visual Science. 2021; 3;62(6):21. View full text
Liu PK, Chang YC, Tai MH, Tsai RK, Chong IW, Wu KY, Wu WC, Hsu CY, Tsai MJ. THE ASSOCIATION BETWEEN CENTRAL SEROUS CHORIORETINOPATHY AND SLEEP APNEA: A Nationwide PopulationBased Study. Retina. 2020 ;40(10):2034-2044. View full text
Shrestha R, Wen YT, Tsai RK. Effective Differentiation and Biological Characterization of Retinal Pigment Epithelium Derived from Human Induced Pluripotent Stem Cells. Current Eye Research. 2020; 45(9):1155-1167. View full text
Liu PK , Wen YT , Lin W , Kapupara K , Tai M , Tsai RK. Neuroprotective efects of lowdose G-CSF plus meloxicam in a rat model of anterior ischemic optic neuropathy. Scientific Reports.2020; 25;10(1):10351. View full text
Lin WN†, Kapupara K†, Wen YT , Chen YH ,Pan IH, Tsai RK. Haematococcus pluvialis-Derived Astaxanthin Is a Potential Neuroprotective Agent against Optic Nerve Ischemia. Marine Drugs.2020;28;18(2):85. View full text
Huang TL†, Wen YT†, Ho YC, Wang JK, Lin KH, Tsai RK. Algae Oil Treatment Protects Retinal Ganglion Cells (RGCs) via ERK Signaling Pathway in Experimental Optic Nerve Ischemia. Marine Drugs. 2020;27;18(2):83. View full text
Shresthaa R, Wen YT, Tsai RK. Generation of hiPSC line TCIERi001-A from normal human epidermal keratinocytes. Stem Cell Research. 2019;41:101590. View full text
Shrestha R, Wen YT, Tsai RK. Induced pluripotent stem cells and derivative photoreceptor precursors as therapeutic cells for retinal degenerations. Tzu Chi Medical Journal. 2019;30;32(2): 101–112. View full text
Nguyen Ngo Le MA, Wen YT, Ho YC, Kapupara K, Tsai RK. Therapeutic Effects of Puerarin Against Anterior Ischemic Optic Neuropathy Through Antiapoptotic and Anti-Inflammatory Actions. Investigative Ophthalmology and Visual Science. 2019;60:3481-3491. View full text
Wen YT, Zhang JR, Kapupara K, Tsai RK. mTORC2 activation protects retinal ganglion cells via Akt signaling after autophagy induction in traumatic optic nerve injury. Experimental & Molecular Medicine. 2019;51:96. View full tex
Kapupara K, Huang TL, Wen YT, Huang SP, Tsai RK. Optic nerve head width and retinal nerve fiber layer changes are proper indexes for validating the successful induction of experimental anterior ischemic optic neuropathy. Experimental & Molecular Medicine. 2019;181:105-111. View full text
Shrestha R, Wen YT, Ding DC, Tsai RK. Aberrant hiPSCs-Derived from Human Keratinocytes Differentiates into 3D Retinal Organoids that Acquire Mature Photoreceptors. Cells. 2019;8. View full text
TL Huang, KH Lin, JK Wang, RK Tsai. Treatment strategies for neuromyelitis optica. Tzu-Chi Medical Journal. 2018; 30(4):204-208. View full text
Ding DC, Wen YT, Tsai RK. Pigment epithelium-derived factor from ARPE19 promotes proliferation and inhibits apoptosis of human umbilical mesenchymal stem cells in serum-free medium. Experimental & Molecular Medicine. 2017;49, e411. View full text
Kapupara K, Wen YT, Tsai RK ,Huang SP. Soluble P-selectin promotes retinal ganglion cell survival through activation of Nrf2 signaling after ischemia injury. Cell Death & Disease. 2017; 8, e3172. View full text
Huang TL, Wang JK, Pang CY, Tsai RK.Leber’s Hereditary Optic Neuropathy Associated with the m.10197G>A Mutation. Journal of Clinical and Experimental Ophthalmology. 2017; 8:673. View full text
Acute Zonal Occult Outer Retinopathy (AZOOR): a case report of vision improvement after intravitreal injection of Ozurdex. Kuo YC, Chen N, Tsai RK. BMC Ophthalmology. 2017; 17:236 . View full text
Wen YT, Tsai RK. The granulocyte colony-stimulating factor (G-CSF) induced stabilization of blood-optic nerve barrier (BOB) in the optic nerve (ON) crush model via PI3K/AKT activation. Investigative Ophthalmology and Visual Science. 2017; 58(8): 1094-1094. View full text
Tsai RK, Wen YT. The roles of autophagy and mTOR in the neuro-protection of optic nerve crush models in rats. Investigative Ophthalmology & Visual Science. 2017; 58(8): 3871-3871. View full text
Chang YH, Liu HW, Chu TY, Wen YT , Tsai RK. Cisplatin-Impaired Adipogenic Differentiation of Adipose Mesenchymal Stem Cells. Cell Transplantation. 2017;26 (6):1077-1087. View full text
Huang TL, Wen YT, Chang CH, Chang SW, Lin KH, Tsai RK. Early Methylprednisolone Treatment Can Stabilize the Blood-Optic Nerve Barrier in a Rat Model of Anterior Ischemic Optic Neuropathy (rAION). Investigative Ophthalmology and Visual Science. 2017; 58:1628-1636. View full text
Georgiou T ,Wen YT, Chang CH, Kolovos P, Kalogerou M, Prokopiou E, Neokleous A, Huang CT, Tsai RK. Neuroprotective Effects of Omega-3 Polyunsaturated Fatty Acids in a Rat Model of Anterior Ischemic Optic Neuropathy. Investigative Ophthalmology and Visual Science. 2017;58:1603-1611. View full text
Tsai MH, Chang CH, Tsai RK, Hong YR, Chuang TH, Fan KT, Peng CW, Wu CY, Hsu WL, Wang LS, Chen LK, Yu HS. Cross-Regulation of Proinflammatory Cytokines by Interleukin-10 and miR-155 in Orientia tsutsugamushi-Infected Human Macrophages Prevents Cytokine Storm. Journal of Investigative Dermatology. 2016;136:1398-1407. View full text
Lee YC, Wang JH, Huang TL, Tsai RK. Increased Risk of Stroke in Patients With Nonarteritic Anterior Ischemic Optic Neuropathy: A Nationwide Retrospective Cohort Study. American Journal of Ophthalmology. 2016;170:183-189. View full text
Huang TL, Wen YT, Chang CH, Chang CW, Lin KH, Tsai RK. Efficacy of Intravitreal Injections of Triamcinolone Acetonide in a Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy. Investigative Ophthalmology and Visual Science. 2016;57:1878-1884. View full text
Huang SP, Fang KT, Chang CH, Huang TL, Wen YT, Tsai RK. Autocrine protective mechanisms of human granulocyte colony-stimulating factor (G-CSF) on retinal ganglion cells after optic nerve crush. Experimental Eye Research. 2016;143:132-140. View full text
Chien JY, Sheu JH, Wen ZH, Tsai RK, Huang SP. Neuroprotective effect of 4-(Phenylsulfanyl)butan-2-one on optic nerve crush model in rats. Experimental Eye Research. 2016;143:148-157. View full text
Cheng HC, Huang TL, Lin KJ, Tsai RK, Woung LC, Yen MY, Wang AG. Summary of the Neuro-Ophthalmology Symposium in the 31st Asia-Pacific Academy of Ophthalmology Congress (APAO 2016). Neuroophthalmology. 2016;40:251-253. View full text
Liu YC, Chen N, Hsu YH, Sheu MM, Tsai RK. Basaloid squamous cell carcinoma of the conjunctiva. Ophthalmic Plastic & Reconstructive Surgery. 2015;31:e28-30. View full text
Lee CH, Lai PS, Lu YP, Chen HY, Chai CY, Tsai RK, Fang KT, Tsai MH, Hsu CY, Hung CC, Wu DC, Yu HS, Chang CH, Tsai DP. Real-time vascular imaging and photodynamic therapy efficacy with micelle-nanocarrier delivery of chlorin e6 to the microenvironment of melanoma. Journal of Dermatological Science. 2015;80:124-132. View full text
Lai YH, Huang SP, Chen SP, Hu PS, Lin SF, Sheu MM, Wang HZ, Tsai RK. A novel gene mutation in a family with X-linked retinoschisis. Journal of the Formosan Medical Association. 2015;114:872-880. View full text
Huang TL, Huang SP, Chang CH, Lin KH, Chang SW, Tsai RK. Protective effects of systemic treatment with methylprednisolone in a rodent model of non-arteritic anterior ischemic optic neuropathy (rAION). Experimental Eye Research. 2015;131:69-76. View full text
Huang TL, Chang CH, Chang SW, Lin KH, Tsai RK. Efficacy of Intravitreal Injections of Antivascular Endothelial Growth Factor Agents in a Rat Model of Anterior Ischemic Optic Neuropathy. Investigative Ophthalmology and Visual Science. 2015;56:2290-2296. View full text
Huang SP, Chien JY, Tsai RK. Ethambutol induces impaired autophagic flux and apoptosis in the rat retina. Disease Models & Mechanisms. 2015;8:977-987. View full text
Huang CT, Chen SP, Tsai RK. The gene mutation in a Taiwanese family with X-linked retinoschisis. The Kaohsiung Journal of Medical Sciences. 2015;31:309-314. View full text
Chen N, Hsieh HP, Tsai RK, Sheu MM. Eye care services for the populations of remote districts in eastern Taiwan: a practical framework using a Mobile Vision Van Unit. Rural and Remote Health. 2015;15:3442. View full text
Huang TL, Huang SP, Chang CH, Lin KH, Sheu MM, Tsai RK. Protective effects of cerebrolysin in a rat model of optic nerve crush. The Kaohsiung Journal of Medical Sciences. 2014;30:331-336. View full text
Huang TL, Huang SP, Chang CH, Lin KH, Sheu MM, Tsai RK. Factors influencing the retrograde labeling of retinal ganglion cells with fluorogold in an animal optic nerve crush model. Ophthalmic Research. 2014;51:173-178. View full text
Huang SP, Tsai RK. Efficacy of granulocyte-colony stimulating factor treatment in a rat model of anterior ischemic optic neuropathy. Neural Regeneration Research. 2014;9:1502-1505. View full text
Cheng HC, Tsai RK, Woung LC, Yen MY, Wang AG. Proceedings of the Neuro-ophthalmology Symposium in the 54th Annual Meeting of the Ophthalmological Society of Taiwan, November 30, 2013, Taipei, Taiwan. Neuroophthalmology. 2014;38:167-169.View full text
Chen N, Huang TL, Hsu YH, Lin HZ, Tsai RK. Orbital Manifestations of Immunoglobulin G4-Related Disease in Bilateral Lacrimal Glands, Optic Nerves, Trigeminal Nerves, and Maxillary Sinuses. Neuroophthalmology. 2014;38:24-28. View full text
Chang CH, Tsai RK, Tsai MH, Lin YH, Hirobe T. The roles of Frizzled-3 and Wnt3a on melanocyte development: in vitro studies on neural crest cells and melanocyte precursor cell lines. Journal of Dermatological Science. 2014;75:100-108. View full text
Chang CH, Huang TL, Huang SP, Tsai RK. Neuroprotective effects of recombinant human granulocyte colony-stimulating factor (G-CSF) in a rat model of anterior ischemic optic neuropathy (rAION). Experimental Eye Research. 2014;118:109-116. View full text
He MS, Sheu MM, Huang ZL, Tsai CH, Tsai RK. Sudden bilateral vision loss and brain infarction following cosmetic hyaluronic acid injection. JAMA Ophthalmology. 2013;131:1234-1235. View full report
Lin HZ, Pang CY, Chen SP, Tsai RK. Vision improvement in a Taiwanese (Han Chinese) family with Leber’s hereditary optic neuropathy. The Kaohsiung Journal of Medical Sciences. 2012;28:679-682. View full text
Hsu SY, Ko ML, Linn G, Chang MS, Sheu MM, Tsai RK. Effects of age and disc area on optical coherence tomography measurements and analysis of correlations between optic nerve head and retinal nerve fibre layer. Clinical and Experimental Optometry. 2012;95:427-431. View full text
Fang TC, Pang CY, Chiu SC, Ding DC, Tsai RK. Renoprotective effect of human umbilical cord-derived mesenchymal stem cells in immunodeficient mice suffering from acute kidney injury. PLOS ONE. 2012;7:e46504. View full text
Chen YJ, Tsai RK, Wu WC, He MS, Kao YH, Wu WS. Enhanced PKCdelta and ERK signaling mediate cell migration of retinal pigment epithelial cells synergistically induced by HGF and EGF. PLOS ONE. 2012;7:e44937. View full report
Chen N, Huang TL, Tsai RK, Sheu MM. Prevalence and causes of visual impairment in elderly Amis aborigines in Eastern Taiwan (the Amis Eye Study). Japanese Journal of Ophthalmology. 2012;56:624-630. View full text
Tsai RK, He MS, Chen ZY, Wu WC, Wu WS. PKCdelta-dependent signaling mediates ethambutol-induced toxic effects on human retinal pigment cells. Molecular Vision. 2011;17:1564-1576. View full text
Huang TL, Chang CH, Lin KH, Sheu MM, Tsai RK. Lack of protective effect of local administration of triamcinolone or systemic treatment with methylprednisolone against damages caused by optic nerve crush in rats. Experimental Eye Research. 2011;92:112-119. View full text