婦女癌症防治中心

主持人:朱堂元/Tang-Yuan Chu

聯絡資訊: TEL 03-856-18235#15610
E-mail:Email住址會使用灌水程式保護機制。你需要啟動Javascript才能觀看它                                                                                              

主持人簡介:

Professor Chu received his MD degree from National Defense Medical Center of Taiwan and PhD degree from Cornell University Medical Center. He was trained in Obstetrics and Gynecology and Gynecologic Oncology in Tri-Service General Hospital, Taiwan. 

In 2005, he was appointed to Tzu Chi Medical Center, Hualien, Taiwan, acting as chiefs of Department of Obstetrics and Gynecology, Department of Research and director of the Center for Prevention and Therapy of Gynecological Centers. 

He was the director of Graduate Institute of Medical Sciences of National Defense Medical Center, and the founder and director of Institute of Clinical Medicine and Institute of Medical Sciences in Tzu Chi University, Taiwan .

Professor Chu’s research focuses on the developmental mechanism of cervical cancer and the ovarian high-grade serous carcinoma (HGSC) and the clinical applications. Special effort was paid on the role of stromal sex-hormone receptors in the development of cervical cancer, and the initiation and promotion of HGSC originating in the fallopian tube epithelium. His research team has recently discovered multiple carcinogens and mechanisms relating to ovulation, responsible for the mutagenesis, mitogenesis and transformation of fallopian tube epithelium in the context of p53 loss. With the in-vitro and in-vivo study systems as well as clinical cohorts and tissue banking, his team is also developing drugs for chemoprevention and biomarkers for early detection of these two cancers.

現職:花蓮慈濟醫院婦產部主任
學歷:美國康乃爾大學醫學院 細胞生物及遺傳學博士
研究興趣/研究主題/研究方向/專長:婦科腫瘤、婦科感染、婦癌篩檢、抹片異常之診斷、腹腔鏡手術、遺傳諮詢
研究領域:癌症遺傳與表觀遺傳、癌症與幹細胞發育、人類乳突病毒與子宮頸癌、卵巢癌         

近期著作發表:

1. Chen YC, Huang RL, Huang YK, Laio YP, Su PH, Wang HC, Chang CC, Lin YW, Yu MH, Chu TY, Lai HC. Methylomics analysis identifies epigenetically silenced genes and implies an activation of β-catenin signaling in cervical cancer. Int J Cancer. 2014 Jul 1;135(1):117-27.(SCI)
2. Ding DC, Chu TY, Hsu YH. Remission of anti-epiligrin cicatricial pemphigoid after excision of cervical adenocarcinoma. Cutan Pathol. 2014 Aug;41(8):692-3. doi: 10.1111/cup.12348. Epub 2014 Apr 26. No abstract available. (SCI)
3. Chu TY*, Yang JT, Huang TH, Liu HW. Crosstalk with cancer-associated fibroblasts increases the growth and radiation survival of cervical cancer cells. Radiat Res. 2014 May;181(5):540-7. doi: 10.1667/RR13583.1. Epub 2014 May 1. (SCI)
4. Lai HC, Ou YC, Chen TC, Huang HJ, Cheng YM, Chen CH, Chu TY, Hsu ST, Liu CB, Hung YC, Wen KC, Yu MH, Wang KL. PAX1/SOX1 DNA methylation and cervical neoplasia detection: a Taiwanese Gynecologic Oncology Group (TGOG) study. Cancer Med.  2014 Aug;3(4):1062-74.
5. Ding DC, Wu KC, Chou HL, Hung WT, Liu HW, Chu TY. Human infra-patellar fat pad-derived stromal cells have more potent differentiation capacity than other mesenchymal cells and can be enhanced by hyaluronan. Cell Transplant. 2015;24(7):1221-32. doi: 10.3727/096368914X681937. Epub 2014 May 21. (SCI)
6. Zhang C, Park JS, Grce M, Hibbitts S, Palefsky JM, Konno R, Smith-McCune KK, Giovannelli L, Chu TY, Picconi MA, Piña-Sánchez P, Settheetham-Ishida W, Coutlée F, De Marco F, Woo YL, Ho WC, Wong MC, Chirenje MZ, Magure T, Moscicki AB, Sabol I, Fiander AN, Chen Z, Chan MC, Cheung TH, Burk RD, Chan PK. Geographical Distribution and Risk Association of Human Papillomavirus Genotype 52-Variant Lineages. J Infect Dis. 2014 Nov 15;210(10):1600-4. doi: 10.1093/infdis/jiu310. Epub 2014 May 30. (SCI)
7. Ding DC, Chu TY, Hsu YH. Large-cell neuro-endocrine carcinoma associated with borderline mucinous tumor of the ovary. Taiwan J Obstet Gynecol. 2014 Jun;53(2):270-2. doi: 10.1016/j.tjog.2013.04.040. No abstract available. (SCI)
8. Su CC, Tseng KC, Lin MN, Hsieh TC, Chu TY*. High seroprevalence of human herpesvirus type 8 in patients with hepatocellular carcinoma. Eur J Clin Microbiol Infect Dis. 2015 Jan;34(1):55-62. doi: 10.1007/s10096-014-2206-8. Epub 2014 Jul 20. (SCI)
9. Su CC, Lai CL, Tsao SM, Lin MN, Chu TY*. High seroprevalence of human herpesvirus type 8 infection in males with advanced lung carcinoma. Med Microbiol Immunol. 2015 Apr;204(2):177-83. doi: 10.1007/s00430-014-0352-3. Epub 2014 Aug 15.
10. Lin H, Chen TC, Chang TC, Cheng YM, Chen CH, Chu TY, Hsu ST, Liu CB, Yeh LS, Wen KC, Huang CY, Yu MH. Methylated ZNF582 gene as a marker for triage of women with Pap smear reporting low-grade squamous intraepithelial lesions - A Taiwanese Gynecologic Oncology Group (TGOG) study. Gynecol Oncol. 2014 Oct;135(1):64-8. doi: 10.1016/j.ygyno.2014.08.012. Epub 2014 Aug 16. (SCI)

完整著作連結請點此

榮譽事項/學術獎勵:

1.         2016慈濟醫院研究卓越獎

2.         2014慈濟醫院優秀研究論文獎｢資深人員組｣第二名

3.         2010年國防醫學院傑出校友獎

4.         2009第十四屆台灣癌症聯合學術年會優秀壁報論文獎（一項）

5.         2008慈濟醫院優秀臨床研究論文獎｢資深人員組｣第一名

6.     2008第十三屆台灣癌症聯合學術年會優秀壁報論文獎（三項）2007第十二屆台灣癌症聯合學術年會優秀壁報論文獎（三項）

相關學會會員資格:

1. 中華民國婦癌醫學會
2. 台灣婦產科醫學會
3. 台灣婦科醫學會
4. 台灣婦癌醫學會

國內外學術期刊與研究審查委員:

1. 國家衛生研究院婦癌臨床指引編撰專家
2. 科技部｢婦幼醫學｣學門複審委員

近年重要會議邀請演講:

• 2016台灣癌症聯合學術年會 
• 2016第三屆湖南省婦科腫瘤國際論壇
• 2015 Biennial conference of Asia Oceania Research Organisation on Genital Infection and Neoplasia(AOGIN)
• 2014 The 6th Biennial conference of Asia Oceania Research Organisation on Genital Infection and Neoplasia(AOGIN)