醫師代碼：23073

專 長

．診斷及治療性內視鏡超音波(EUS)：胰臟、膽道及消化道黏膜下腫瘤診治

．巴瑞特氏食道症(Barrett's esophagus)內視鏡射頻消融術(RFA)治療

．內視鏡抗逆流黏膜燒灼術(ARMA)治療

．肝癌射頻燒灼術(RFA)治療

．胃食道逆流症96小時無線膠囊酸鹼檢測

．脂肪肝、B、C型肝炎、慢性肝炎及肝硬化治療

．胃食道逆流、咽喉逆流症、胃、十二指腸潰瘍、脹氣消化不良

．腸躁症(IBS)、發炎性腸道疾病(IBD)

．胃鏡及大腸鏡、內視鏡息肉及腫瘤切除術、腹部超音波

現 職

．花蓮慈濟醫院肝膽腸胃科  主治醫師

．慈濟大學醫學院 部定助理教授

學 歷

．台北醫學大學 醫學士

．慈濟大學藥理暨毒理學研究所 博士

經 歷

．美國西北大學(Northwestern Medicine)訪問學者

．日本東京大學醫學部附屬病院 內視鏡超音波(EUS)研修

．日本順天堂大學 肝癌射頻燒灼術(RFA)訓練

．台北馬偕醫院肝膽腸胃科 主治醫師

．台東馬偕醫院肝膽腸胃科 主治醫師

．台北馬偕醫院肝膽腸胃科 研究醫師

．台北馬偕醫院內科部 住院醫師及總醫師

專科證書

．內科專科醫師證書

．消化系內科專科醫師證書

．消化系內視鏡專科醫師證書

．醫教會一般醫學師資

專科學會

．台灣內科醫學會

．台灣消化系醫學會

．台灣消化系內視鏡醫學會

．台灣發炎性腸道疾病學會

．台灣胃腸神經與蠕動學會

．台灣微菌聯盟

．美國胃腸科醫學會

著 作

1. Esophageal hypervigilance and visceral anxiety contribute to symptom severity of laryngopharyngeal reflux. Wong MW, Hsiao SH, Wang JH, Yi CH, Liu TT, Lei WY, Hung JS, Liang SW, Lin L, Gyawali CP, Chen PR and Chen CL. American Journal of Gastroenterology 2023 May 1;118(5):786-793.

2. Artificial intelligence facilitates measuring reflux episodes and post reflux swallow-induced peristaltic wave index from impedance-pH studies in patients with reflux disease. Wong MW, Liu MX, Lei WY, Liu TT, Yi CH, Hung JS, Liang SW, Lin L, Tseng CW, Wang JH, Wu PA, Chen CL.Neurogastroenterol Motil. 2023 Mar;35(3):e14506.

3. Esophageal secondary peristalsis following acid infusion and chemical clearance correlate with mucosal integrity and acid sensitivity in GERD patients. Wong MW, Hung JS, Lei WY, Liu TT, Yi CH, Liang SW, Gyawali CP, Wang JH, Chen CL. Therap Adv Gastroenterol. 2023 Jun 29;16:17562848231179329.

4. Oesophageal hypervigilance and visceral anxiety relate to reflux symptom severity and psychological distress but not to acid reflux parameters.Wong MW, Liu TT, Yi CH, Lei WY, Hung JS, Cock C, Omari T, Gyawali CP, Liang SW, Lin L, Chen CL. Aliment Pharmacol Ther. 2021 Oct;54(7):923-930

5. Analysis of contractile segment impedance during straight leg raise maneuver using high-resolution impedance manometry increases diagnostic yield in reflux disease. Wong MW, Liu TT, Yi CH, Lei WY, Hung JS, Omari T, Cock C, Liang SW, Gyawali CP, Chen CL. Neurogastroenterology & Motility. 2021;00:e14135.

6. Effect of prucalopride on sildenafil-induced inhibition of esophageal peristalsis in healthy adults. Wong MW, Liu TT, Yi CH, Hung JS, Lei WY, Liang SW, Orr WC, Chen CL. J Gastroenterol Hepatol. 2021 Jun;36(6):1556-1561.

7. Esophageal acid burden in reflux patients with normal endoscopy: Does esophageal peristalsis matter? Wong MW, Hung JS, Liu TT, Yi CH, Lei WY, Liang SW, Orr WC, Chen CL. J Formos Med Assoc. 2021 Jun 2;S0929-6646(21)00236-9

8. Effects of phosphodiesterase-5 inhibitor sildenafil on esophageal secondary peristalsis: studies with high-resolution manometry. Wong MW, Yi CH, Liu TT, Lei WY, Hung JS, Liu CZ, Chen CL. J Gastroenterol Hepatol. 2021 Feb;36(2):430-435.

9. Influence of sildenafil on esophageal motor function in humans: studies using high-resolution manometry. Wong MW, Hung JS, Lei WY, Liu TT, Yi CH, Chen CL. Neurogastroenterol Motil. 2020 Apr 23;e13840.

10. Esophageal acid sensitivity in patients with gastroesophageal reflux disease: does esophageal hypomotility matter? Wong MW, Hung JS, Lei WY, Liu TT, Yi CH, Chen CL. Neurogastroenterol Motil. 2019 Nov;31(11):e13700.

11. Clinical and psychological characteristics in gastroesophageal reflux disease patients overlapping with laryngopharyngeal reflux symptoms. Wong MW, Bair MJ, Chang WC, Hsu CS, Hung JS, Liu TT, Yi CH, Lei WY, Vaezi MF, Gyawali CP, Chen CL.J Gastroenterol Hepatol. 2019 Oct;34(10):1720-1726.

12. Gamma‐aminobutyric acid receptor type B agonist baclofen inhibits acid‐induced excitation of secondary peristalsis but not heartburn sensation. Wong MW, Hung JS, Liu TT, Yi CH, Lei WY, Chen CL. J Gastroenterol Hepatol. 2019 Feb;34(2):370-375.

13. Assessment of esophageal function using provocative tests during high resolution manometry: a single-center experience. Wong MW, Lei WY, Hung JS, Liu TT, Yi CH, Chen CL. J Formos Med Assoc 2019 Jan;118(1 Pt 2):244-248.

14. Validated Clinical Score to Predict Gastroesophageal Reflux in Patients With Chronic Laryngeal Symptoms: COuGH RefluX. Amanda J Krause, Alexander M Kaizer, Dustin A Carlson, Walter W Chan, Chien-Lin Chen, C Prakash Gyawali, Andrew Jenkins, John E Pandolfino, Vinathi Polamraju, Ming-Wun Wong, Madeline Greytak, Rena Yadlapati. Clin Gastroenterol Hepatol. 2024 Jun;22(6):1200-1209.e1.

15. Diagnostic Yield of Ambulatory Reflux Monitoring Systems for Evaluation of Chronic Laryngeal Symptoms. Amanda J Krause, Madeline Greytak, Alexander M Kaizer, Dustin A Carlson, Walter W Chan, Chien-Lin Chen, C Prakash Gyawali, Andrew Jenkins, John E Pandolfino, Vinathi Polamraju, Ming-Wun Wong, Rena Yadlapati Am J Gastroenterol. 2024 Apr 1;119(4):627-634.

專利

．Computer-Assisted Medical Analysis System and Method, Device, Computer Storage Medium and Computer Program Product For Interpreting Gastroesophageal Reflux Disease Using Artificial Intelligence.

發明人：翁銘彣、劉民翔、吳彬安、陳健麟
專利證書字號：發明第I817685號

醫師代碼：2306

專 長

• 一般胃腸肝膽科
• 慢性肝炎
• 肝硬化
• 肝癌
• 分子生物學
• 分子遺傳學
• 遺傳病及癌症的分子醫學診斷
• 經鼻內視鏡
• 腹部超音波
• 癌症自然醫學輔助療法

現 職

• 內科部肝膽腸胃研究中心主任
• 內科部肝膽腸胃科主治醫師
• 研究部肝病研究中心專題研究室主持人
• 慈濟大學部定教授

 
學 歷

• 台北醫學大學醫學士
• 英國劍橋大學分子生物學博士

經 歷

• 台北馬偕醫院內科部住院醫師
• 台北醫學大學附設醫院腸胃肝膽科研究員、總醫師
• 慈濟醫院人體試驗計劃審議委員會總幹事、內科部副主任、消化系功能檢查室主任、肝膽腸胃科主任
• 慈濟大學醫學系腸胃肝膽科主任
• 英國劍橋大學附設醫院（Addenbrooke’s Hospital）分子肝膽暨肝移植中心研究員
• 德國柏林分子醫學中心（Max Delbruck Center for Molecular Medicine）研究員
• 美國國家衛生院（National Institutes of Health）肝病研究中心博士後研究員
• 美國堪薩斯州威奇托Riordon Clinic整合自然醫學中心進修

簡易介紹
專科證書

• 內科專科醫師證書
• 消化系內視鏡專科醫師證書
• 消化系醫學會專科醫師證書
• 針灸專科醫師證書

• 台灣內科醫學會
• 台灣消化系醫學會
• 台灣消化系內視鏡醫學會（第八屆、第九屆理事）
• 台灣肝臟研究學會
• 中華針灸醫學會

【專書】

• Wen-Sheng Wu, Chi-Tan HuEditors. Signal Transduction in Cancer Metastasis. Cancer metastasis- Biology and Treatment 15. Springer 2010.【DOI: 10.1007/978-90-481-9522-0, ISBN: 978-90-481-9521-3 (eISBN: 978-90-481-9522-0)】
• Wen-Sheng Wu, Chi-Tan Hu*. Chapter 2: Microenvironment Triggers EMT, Migration and Invasion of Primary Tumor via Multiple Signal Pathways. Cancer metastasis-Biology and Treatment 15: 9-24. Springer 2010 Nov.
• Chi-Tan Hu, Jia-Ru Wu, Wen-Sheng Wu*. Chapter 7: Signal Cross Talks for Sustained MAPK Activation and Cell Migration Mediated by Reactive Oxygen Species: The Involvement in Tumor Progression. Cancer metastasis-Biology and Treatment 15: 119-136. Springer 2010 Nov.
• Selena Y. Lin, Surbhi Jain, Wei Song, Chi-Tan Hu, Ying-Hsiu Su. Chapter 7: Strategic Assay Developments for Detection of HBV 1762T/1764A Double Mutation in Urine of Patients with HBV-Associated Hepatocellular Carcinomas. Hepatocellular Carcinoma-Clinical Research: 139-154. InTech 2012 Mar.【DOI: 10.5772/2483, ISBN 978-953-51-0112-3】
• Chi-Tan Hu, CL Chen, Zhen-Xiong Lin. Ch.6 Miscellaneous Disorders. 9. Small Bowel Tapeworm. Atlas of Small Intestinal Disorders: Integrated Case Presentation. P206-209. Ho-Chi Book Publishing Co. 2014 Jan.【ISBN 978-986-368-001-7】
• 胡志棠. Part 2認識肝硬化發病原因與預防. 2-3肝硬化的症狀及徵兆. 肝硬化全書-全國護肝專家教你預防、照護、治療36-46. 如何出版社有限公司2014年5月.【ISBN 978-986-136-389-9】

【影片】

• 大愛電視台「人體的奧秘系列：人體的超級工廠-肝臟」影片科學顧問（國科會補助） (2014年1月11日首播) 

【專利】

• 魏誠佑、謝昌衛、盧崑山、夏靜吾、龍輝、蕭正忠、胡志棠。用以治療癌症及／或腫瘤之到手香葉汁LEAF JUICE OF PLECTRANTHUS AMBOINICUS FOR TREATING CANCER AND/OR TUMOR。（專利證書號數I399210）
• 高立人、鍾承璋、胡志棠、陳明賢。基於雲端運算技術之影像處理系統。(發明第I498747號)

【近五年期刊論文】

• Chi-Tan Hu, K. M. O'Shaughnessy. Glycerol-enhanced mini-polyacrylamide gel electrophoresis for the separation of differentially expressed DNA fragments in cDNA representational difference analysis. Electrophoresis 22(6): 1063-1068, 2001 Apr.
• Hans Hsienhong Lin, Li-Yu Wang, Chi-Tan Hu, Shih-Che Huang, Lu-Chin Huang, Sherry S.J. Lin, Yu-Ming Chiang, Tso-Tsai Liu, Chien-Lin Chen. Decline of Hepatitis B Carrier Rate in Vaccinated and Unvaccinated Subjects: Sixteen Years After Newborn Vaccination Program in Taiwan. J Med Virol69(4): 471-474, 2003Apr.
• Ya-Fang Wu, Li-Yu Wang, Tsung-Dao Lee, Hans Hsienhong Lin, Chi-Tan Hu, Mu-Liang Cheng Shih-Yen Lo. HLA Phenotypes and Outcomes of Hepatitis B Virus Infection in Taiwan. J Med Virol 72(1): 17-25, 2004 Jan.
• Chao-Chuan Wu, Yao-Jen Chang, Hisen-Hong Lin, Shih-Che Huang, Lu-Chin Huang, Chi-Tan Hu, Zuo-Chai Liu, Jian-Lin Chen, Nien-Tsung Lin. Analyses the Virulent Gene Status of Clinical Isolate Helicobacter Pylori from Han Chinese and Aboriginals of Eastern Taiwan.Tzu Chi Med J16(1): 33-42, 2004 Feb.
• Chien-Lin Chen, Hsien-Hong Lin, Lu-Chin Huang, Shi-Che Huang,Chi-Tan Hu, Tso-Tsai Liu. Gastric Myoelectrical Activity in Gastroesophageal Reflux Disease Overlapping with Dysmotility-like Dyspepsia. Gastroenterol J Taiwan 21(1): 1-10, 2004 Mar.
• Bang-Gee Hsu, Shih-Yen Lo, Li-Yu Wang, Hsin-Chieh Ma, Chih-Hsien Wang, Ching-Shing Liao, Chi-Tan Hu, Hans Hsienhong Lin*. TT Virus Infection in Patients on Maintenance Hemodialysis in Eastern Taiwan. Acta Nephrologica18:71-74, 2004.
• Chi-Tan Hu, Hans Hsien-Hong Lin. Multifocal Inflammatory Pseudotumors in A Patient with Cirrhotic Liver and Very High Alpha-Fetoprotein: Report of A Case. Gastroenterol J Taiwan 21(2): 155-162, 2004 Jun.
• Chi-Tan Hu. An In Vitro System for the Study of Hepatitis B Gene Expression. Tzu Chi Med J 16(5): 293-300. 2004 Oct.
• Li-Yu Wang, Hans Hsienhong Lin, Tsung-Dao Lee, Ya-Fang Wu, Chi-Tan Hu, Mu-Liang Cheng, Shih-Yen Lo*. Human leukocyte antigen phenotypes and hepatitis C viral load. Journal of Clinical Virology 32(2):144-150, 2005 Feb.(SCI)
• Chi-Tan Hu*. Vaccine Development for Hepatitis C: Lessons from the Past Turn into Promise for the Future. Tzu Chi Medical Journal 17(2):61-74, 2005 Apr.Lu-Chin Huang*, Hans Hsienhong Lin, Shih-Che Huang, Chi-Tan Hu, Tso-Tsai Liu, Chien-Lin Chen, Yao-Jen Chang, Pau-Nyen Chong. Gastrointestinal Bezoar: Clinical Study of 15 Years Experience from A Medical Center in Eastern Taiwan. Tzu Chi Medical Journal 17(2):83-86, 2005 Apr.
• Chi-Tan Hu*. Gene Expression Profiling of the Liver in Chimpanzees during HCV Infection Using Microarray: Genes Related to Viral Persistence and Clearance. Tzu Chi Medical Journal 17(3):145-154, 2005 Jun.
• Chao-Chuan Wu, Pai-Yu Chou, Chi-Tan Hu, Zuo-Chai Liu, Chih-Yung Lin, Yi-Hsiung Tseng, and Nien-Tsung Lin^*  .Clinical Relevance of the vacA, iceA, cagA, and flaA genes of Helicobacter pylori strains isolated in Eastern Taiwan. Journal of Clinical Microbiology 43(6):2913-2915, 2005 Jun.(SCI)
• Bang-Gee Hsu, Shih-Yen Lo, Li-Yu Wang, Chih-Hsien Wang, Ching-Shing Liao, Chi-Tan Hu, Hans Hsienhong Lin*. Hepatitis G Virus Viremia is Rare in Patients at One Maintenance Hemodialysis Center in Eastern Taiwan. Tzu Chi Medical Journal 17(3):155-158, 2005 Jun.
• Ming-Cheh Chen*, Chi-Tan Hu, Li-Yu Wang, Hsien-Hong Lin. The efficacy of Helicobacter pylori eradication related to CYP2C19 metabolism. Alimentary Pharmacology & Therapeutics 22(3):274-275; author reply 275-276, 2005 Aug 1. [Letters to the Editors].(SCI)
• Tso-Tsai Liu, Chi-Tan Hu*. 糖尿病、高血脂症及肥胖與脂肪肝的關係及治療. Tzu Chi Medical Journal 18(Suppl 1):53-55, 2006 Feb.
• Li-Yu Wang, Chi-Tan Hu, Tzu-Ying Ho, Hans Hsienhong Lin*. Geographic and ethnic variations of long-term efficacy and immunogenicity of hepatitis B vaccination in Hualien, a HBV hyperendemic area. Vaccine 24(20):4427-4432, 2006 May. (SCI)
• Tso-Tsai Liu, Hans-Hsienhong Lin, Li-Yu Wang, Shih-Yen Lo, Teng-Yi Lin, Chi-Tan Hu, Chih-Hsien Wang, Te-Chao Fang, Bang-Gee Hsu*. SEN Virus Infection in Patients on Maintenance Hemodialysis in Eastern Taiwan. Tzu Chi Medical Journal 18(3):179-183, 2006 Jun.
• Chien-Lin Chen*, Chi-Tan Hu, Hsien-Hong Lin, Chih-Hsun Yi. Clinical utility of electrogastrography and the water load test in patients with upper gastrointestinal symptoms. Journal of Smooth Muscle Research 42(5):149-157, 2006 Oct.
• Bang-Gee Hsu, Li-Yu Wang, Chi-Tan Hu, Chih-Hsien Wang, Te-Chao Fang, and Hans Hsienhong Lin*. SEN virus infection in patients on peritoneal dialysis. Peritoneal Dialysis International 27(1):74-78, 2007 Jan-Feb. (SCI)
• Li-Yu Wang*, Tzu-Ying Ho, Ming-Che Chen, Chi-Shun Yi, Chi-Tan Hu, Hans Hsienhong Lin. Prevalence and determinants of SENV viremia among adolescents in an endemic area of chronic liver diseases. Journal of Gastroenterology and Hepatology 22(2):171-176, 2007 Feb. (SCI)
• Chi-Tan Hu, Chao-Chuan Wu, Chih-Yung Lin, Chuan-Chu Cheng, Siou-Cing Su, Yi-Hsiung Tseng, Nien-Tsung Lin*. Resistance rate to antibiotics of Helicobacter pylori isolates in eastern Taiwan. Journal of Gastroenterology and Hepatology 22(5):720-723, 2007 May. (SCI)
• Bang-Gee Hsu, Li-Yu Wang,Chi-Tan Hu, Chih-Hsien Wang, Te-Chao Fang, Hans Hsienhong Lin*. TT Virus Infection in Patients on Peritoneal Dialysis in Taiwan. Renal Failure 29(5): 553-557, 2007 Jun. (SCI)
• Chih-Hsun Yi, Chi-Tan Hu, Chien-Lin Chen*. Sleep Dysfunction in Patients with GERD:Erosive Versus Nonerosive Reflux Disease. American Journal of the Medical Sciences 334(3):168-170, 2007 Sep. (SCI)Chi-Tan Hu*. Ultrathin Transnasal Endoscopy: Experience of Six Hundred Cases.Gastroenterological Journal of Taiwan 24(3):263-272, 2007 Sep.
• Chi-Tan Hu*. Endoscopic-Guided Versus Cotton-Tipped Applicator Methods of Nasal Anesthesia for Transnasal Esophagogastroduodenoscopy: A Randomized, Prospective, Controlled Study. American Journal of Gastroenterology 103(5):1114-1121, 2008 May. (SCI)Chi-Tan Hu, Jia-Ru Wu, Tsu Yao Chang, Chuan-Chu Cheng, Wen-Sheng Wu*.The transcriptional factor Snail simultaneously triggers cell cycle arrest and migration of human hepatoma HepG2. Journal of Biomedical Science 15(3):343-355, 2008 May. (SCI)
• Wen-Sheng Wu*, Jia-Ru Wu, Chi-Tan Hu. Signal cross talks for sustained MAPK activation and cell migration: the potential role of reactive oxygen species. Cancer and Metastasis Reviews 27(2):303-314, 2008 Jun. (SCI)
• Wei-Yi Lei, Ming-Cheh Chen, Chi-Tan Hu*, Lu-Chin Huang, Shih-Che Huang. Progression of a prepyloric hyperplastic polyp. Gastrointestinal Endoscopy 68(3):570, 2008 Sep. (SCI)
• Chi-Tan Hu*. Endoscopic-Guided Versus Cotton-Tipped Applicator Methods of Nasal Anesthesia for Transnasal Esophagogastroduodenoscopy: A Randomized, Prospective, Controlled Study.  Response to Dr. Dumonceau et al. American Journal of Gastroenterology 103(12):3209-3210, 2008 Dec. (SCI)
• Tso-Tsai Liu, Chi-Shun Yi, Andy Shau-Bin Chou, Ming-Che Lee, Ming-Cheh Chen, Li-Yu Wang, Hans Hsienhong Lin, Chi-Tan Hu*. Comparison Between the CLIP and Okuda Staging Systems for Prediction of Survival Time of Patients with Hepatocellular Carcinoma in Eastern Taiwan. Tzu Chi Medical Journal 21(1):34-39, 2009 Mar.\ Chi-Tan Hu, Pei-Yu Chiou, Chao-Chuan Wu, Yi-Hsiung Tseng, Yao-Jen Chang, Nien-Tsung Lin*. Analysis of Resistance to Clarithromycin and Virulence Markers in Helicobacter pylori Clinical Isolates from Eastern Taiwan. Tzu Chi Medical Journal 21(2):123-128, 2009 Jun.
• J. Lin, M. Chen,W. Lei,W. Law, C. Hu*. Eradication of diffuse gastric Peutz-Jeghers polyps by unsedated transnasal snare polypectomy and argon plasma coagulation. Endoscopy 41(Suppl 2):E207-208, 2009 Nov. (SCI)Chi-Tan Hu*. Gauze pledgetting versus endoscopic-guided aerosolized spray for nasal anesthesia before transnasal EGD: a prospective, randomized study. Gastrointestinal Endoscopy 71(1): 11-20, 2010 Jan. (SCI)
• Chi-Tan Hu, Tsu-Yao Chang, Chuan-Chu Cheng, Chun-Shan Liu, Jia-Ru Wu, Ming-Che Li, Wen-Sheng Wu*. Snail associates with EGR-1 and SP-1 to upregulate transcriptional activation of p15^INK4b. FEBS Journal 277(5): 1202-1218, 2010 Mar. (SCI)
• Chi-Tan Hu*. Nasal anesthesia and body position changes: lessons learned from self-performed, transnasal EGD. Gastrointestinal Endoscopy 71(7): 1277-1279, 2010 Jun. (SCI)
• Chi-Tan Hu, Wei-Yi Lei*, Ming-Cheh Chen, Andy Shau-Bin Chou. An unusual complication of peptic ulcer disease. Gastrointestinal Endoscopy 72(2): 433-434, 2010 Aug. (SCI)C. Hu*. Reporting the how, where, and grading of nasomucosal injury after transnasal endoscopy. Endoscopy 42(8): 688-689, 2010 Aug. (SCI)
• Wei-Yi Lei, Ming-Cheh Chen, Chi-Tan Hu*. Effects of study design and different criterion standards on diagnostic accuracy of ultrathin endoscopy. Gastrointestinal Endoscopy72(4): 901-902, 2010 Oct. (SCI)Chi-Tan Hu*.Remaining in an Upright Position Is Suboptimal for Transnasal Gastroscopy. American Journal of Gastroenterology105(10): 2295-2296; author reply 2296-2297, 2010 Oct. (SCI)
• Chi-Tan Hu*. The SET maneuvers for reducing left-hand strain while doing colonoscopy in a sitting position. Gastrointestinal Endoscopy73(3): 639-640. 2011 Mar. (SCI)
• Wen-Lin Lo, Andy Shau-Bin Chou, Chi-Tan Hu, Jung-Cheng Kang, Wei-Yi Lei, Ta-Chung Wu, Ming-Cheh Chen*. A rare endoscopic finding of GI stromal tumor.Gastrointestinal Endoscopy73(3): 612-613. 2011 Mar. (SCI)
• Hao-Chun Yu, Yung-Hsiang Hsu, Chi-Tan Hu*. A Woman with Improving Cholestasis but Hepatitis Aggravating. Hepatology53(6): 2136-2137. 2011 Jun. (SCI)
• Selena Y. Lin, Veerpal Dhillon, Surbhi Jain, Ting-Tsung Chang, Chi-Tan Hu, Yih-Jyh Lin, Shun-Hua Chen, Kung-Chao Chang, Wei Song, Lixin Yu, Timothy M. Block, Ying-Hsiu Su*. A Locked Nucleic Acid Clamp-Mediated PCR Assay for Detection of a p53 Codon 249 Hotspot Mutation in Urine. Journal of Molecular Diagnostics 13(5):474-484. 2011 Sep. (SCI)
• C. T. Hu*. Transnasal pharyngoscopy to assist nasobiliary tube placement: a simple technique to avoid injury to the patient, endoscopist, and endoscope. Endoscopy43(10):923-924. 2011 Oct. (SCI)
• Surbhi Jain, Ting-Tsung Chang, James P. Hamilton, Selena Y. Lin, Yih-Jyh Lin, Alison A. Evans, Florin M. Selaru, Pin-Wen Lin, Shun-Hua Chen, Timothy M. Block, Chi-Tan Hu, Wei Song, Stephen J. Meltzer, Ying-Hsiu Su*. Methylation of the CpG Sites Only on the Sense Strand of the APC Gene Is Specific for Hepatocellular Carcinoma. PLoS One 6(11):e26799, 1-12. 2011 Nov.(SCI)
• Chi-Tan Hu, Jia-Ru Wu, Chuan-Chu Cheng, Sindy Wang, Hsiao-Ting Wang, Ming-Che Lee, Ling-Jung Wang, Siou-Mei Pan, Tsu-Yao Chang, Wen-Sheng Wu*. Reactive oxygen species-mediated PKC and integrin signaling promotes tumor progression of human hepatoma HepG2. Clinical & Experimental Metastasis28(8):851-863. 2011 Dec. (SCI)
• Surbhi Jain, Sitong Chen, Kung-Chao Chang, Yih-Jyh Lin, Chi-Tan Hu^#, Batbold Boldbaatar, James P. Hamilton, Selena Y. Lin, Ting-Tsung Chang, Shun-Hua Chen, Wei Song, Stephen J. Meltzer, Timothy M. Block, Ying-Hsiu Su*. Impact of the Location of CpG Methylation within the GSTP1 Gene on Its Specificity as a DNA Marker for Hepatocellular Carcinoma. PLoS One 7(4):e35789, 1-11. 2012 Apr. (SCI)
• Hsiang-Yao Shih, Sophie S.W.Wang, Chao-Hung Kuo, Fu-Chen Kuo, Yi-Yu Chen, Meng-ChiehWu, Bi-ChuangWeng, Yi-Chern Lee, Chi-Tan Hu, Deng-ChyangWu, Yen-Hsu Chen*. Comparison between Single-Dose Esomeprazole- and Pantoprazole-Based Triple Therapy on the Effectiveness for Helicobacter pylori Eradication in Taiwanese Population. Gastroenterology Research and Practice2012(ID 674324):1-5. 2012 Jul 4 Epub. (SCI)
• Ta-Chung Wu, Wei-Yi Lei, Ming-Cheh Chen, Chi-Tan Hu*. Strongyloides stercoralis infection: a health issue regarding indigenous people in Taiwan. Transactions of the Royal Society of Tropical Medicine and Hygiene 106(8): 468-472. 2012Aug. (SCI)
• Chi-Tan Hu*. Cotton pledget packing versus topical spray for nasal preparation: merits and demerits are answered by a strict randomized controlled trial. European Archives of Oto-Rhino-Laryngology270(5):1763-1764. 2013 May. (SCI)
• Chi-Tan Hu, Chuan-Chu Cheng, Siou-Mei Pan, Jia-Ru Wu, Wen-Sheng Wu*. PKC mediates fluctuant ERK-paxillin signaling for hepatocyte growth factor-induced migration of hepatoma cell HepG2. Cellular Signalling 25(6):1457-1467, 2013 Jun. (SCI)
• Chi-Tan Hu, Jia-Ru Wu, Wen-Sheng Wu*. The role of endosomal signaling triggered by metastatic growth factors in tumor progression. Cellular Signalling 25(7):1539-1545.2013 Jul.(SCI)
• Wen-Lin Lo, Jen-Shung Lin, Wei-Yi Lei, Hao-Chun Yu, Li-Keng Chao, Jui-Sheng Hung, Daw-Chian Tang, Chi-Tan Hu*. Transnasal Endoscopy: Savior for Patients with Endoscopy Phobia. Journal of Internal Medicine of Taiwan 24(4):271-277. 2013 Aug.
• Chi-Tan Hu*. Let your patients watch and talk during examination: A review of unsedated transnasal endoscopy. Tzu Chi Medical Journal 25(3):139-145. 2013 Sep.
• Ming-Cheh Chen, Chih-Hsun Yi, Li-Yu Wang, Hans Hsienhong Lin, Chi-Tan Hu*. Difference in the Prevalence of CYP2C19 Poor Metabolizers Among Racial and Ethnic Groups of Eastern Taiwan. Gastroenterological Journal of Taiwan30(4):300-308. 2013 Dec.
• Jen-Shung Lin, Wen-Lin Lo, Wei-Yi Lei, Hao-Chun Yu, Li-Keng Chao, Rui-Sheng Hong, Dau-Chen Tang, Chi-Tan Hu*. Historic Progress and New Trend of Nasoenteric Tube Placement. Journal of Internal Medicine of Taiwan 24(6):461-468.2013 Dec.
• Rong-Nan Chien, Cheng-Yuan Peng, Jia-Horng Kao, Tsung-Hui Hu, Chun-Che Lin, Chi-Tan Hu, Chi-Yi Chen, Tsai-Yuan Hsieh, Han-Chieh Lin, Wan-Long Chuang*, on behalf of the Taiwan NA-Registry Group. Higher adherence with 3-year entecavir treatment than lamivudine or telbivudine in treatment-naïve Taiwanese patients with chronic hepatitis B. Journal of Gastroenterology and Hepatology29(1):185-192. 2014 Jan. (SCI)
• Ming-Cheh Chen, Wei-Yi Lei, Jen-Shung Lin, Chih-Hsun Yi, Deng-Chyang Wu, Chi-Tan Hu*.Levofloxacin-Amoxicillin/Clavulanate-Rabeprazole versus a Standard Seven-Day Triple Therapy for Eradication of Helicobacter pylori Infection. BioMed Research International (Journal of Biomedicine and Biotechnology)2014(ID 158520):1-7. 2014 Jun. (SCI)
• Jia-Ru Wu, Chi-Tan Hu, Ren-In You, Pei-Ling Ma, Siou-Mei Pan, Ming-Che Lee, Wen-Sheng Wu*. Preclinical Trials for Prevention of Tumor Progression of Hepatocellular Carcinoma by LZ-8 Targeting c-Met Dependent and Independent Pathways. PLoS One 10(1):e0114495, 1-19. 2015 Jan. (SCI)
• Chao-Chuan Wu, Chi-Tan Hu^#, Ming-Che Lee, Yao-Jen Chang, Siou-Mei Pan, Jia-Ru Wu, Shu-Chuan Lin, Wen-Sheng Wu*. Prevention of Hepatocellular carcinoma progression by the Chinese herb derived peptide Lingzhi-8. Journal of Nature and Science1(3):e50, 1-3. 2015 Mar.
• Guang-Hong Jheng, I-Chen Wu, Hsiang-Yao Shih, Meng-Chieh Wu, Fu-Chen Kuo, Huang-Ming Hu, Chung-Jung Liu, Wen-Hung Hsu, Chi-Tan Hu, Ming-Jong Bair, Chao-Hung Kuo, Deng-ChyangWu, Ping-I Hsu*. Comparison of Second-Line Quadruple Therapies with or without Bismuth for Helicobacter pylori Infection. BioMed Research International (Journal of Biomedicine and Biotechnology)2015(ID 163960):1-6. 2015 May. (SCI)
• Surbhi Jain, Ting-Tsung Chang, Sitong Chen, Batbold Boldbaatar, Adam Clemens, Selena Y. Lin, Ran Yan, Chi-Tan Hu, Haitao Guo, Timothy M. Block, Wei Song, Ying-Hsiu Su*. Comprehensive DNA methylation analysis of hepatitis B virus genome in infected liver tissues. Scientific Reports5(10478):1-11. 2015 May (SCI)
• Chi-Tan Hu, Chuan-Chu Cheng, Jia-RuWu, Siou-Mei Pan, Wen-Sheng Wu*. PKCε-mediated c-Met endosomal processing directs fluctuant c-Met-JNK-paxillin signaling for tumor progression of HepG2. Cellular Signalling 27(7):1544-1555. 2015 Jul. (SCI)
• Jia-Ru Wu, Chi-Tan Hu, Ren-In You, Siou-Mei Pan, Chuan-Chu Cheng, Ming-Che Lee, Chao-Chuan Wu, Yao-Jen Chang, Shu-Chuan Lin, Chang-Shan Chen, Teng-Yi Lin, Wen-Sheng Wu*. Hydrogen peroxide inducible clone-5 mediates reactive oxygen species signaling for hepatocellular carcinoma progression. Oncotarget6(32):32526-32544. 2015 Oct. (SCI)
• Surbhi Jain, Lijia Xie,Batbold Boldbaatar, Selena Y. Lin, James P. Hamilton, Stephen J. Meltzer, Shun-Hua Chen, Chi-Tan Hu, Timothy M. Block, Wei Song*, Ying-Hsiu Su*. Differential methylation of the promoter and first exon of the RASSF1A gene in hepatocarcinogenesis. Hepatology Research45(11):1110-1123. 2015 Nov. (SCI)
• Chi-Tan Hu*. Anterior meatuscopy is more reliable than a sniff test for predicting nasal patency before transnasal endoscopy. Endoscopy International Open3(6):E538-E546. 2015 Dec.
• Chung-Yi Lin, Chi-Tan Hu, Chuan-Chu Cheng, Ming-Che Lee, Siou-Mei Pan, Teng-Yi Lin, Wen-Sheng Wu*. Oxidation of heat shock protein 60 and protein disulfide isomerase activates ERK and migration of human hepatocellular carcinoma HepG2. Oncotarget7(10):11067-11082. 2016 Mar. (SCI)
• Tung-Hung Su, Tsung-Hui Hu, Chi-Yi Chen, Yi-Hsiang Huang, Wan-Long Chuang, Chun-Che Lin, Chia-Chi Wang, Wei-Wen Su, Ming-Yao Chen, Cheng-Yuan Peng, Rong-Nan Chien, Yi-Wen Huang, Horng-Yuan Wang, Chih-Lin Lin, Sheng-Shun Yang, Tsung-Ming Chen, Lein-Ray Mo, Shih-Jer Hsu, Kuo-Chih Tseng, Tsai-Yuan Hsieh, Fat-Moon Suk, Chi-Tan Hu, Ming-Jong Bair, Cheng-Chao Liang, Yung-Chao Lei, Tai-Chung Tseng, Chi-Ling Chen, Jia-Horng Kao*, on behalf of the C-TEAM study group and the Taiwan Liver Diseases Consortium. Four-year entecavir therapy reduces hepatocellular carcinoma, cirrhotic events and mortality in chronic hepatitis B patients. Liver International36(12):1755-1764. 2016Dec. (SCI)
• Shi-Ming Lin*, Sheng-Nan Lu, Ping-Tsung Chen, Long-Bin Jeng, Shinn-Cherng Chen, Chi-Tan Hu, Sien-Sing Yang, Marie-Aude Le Berre, Xuan Liu, David Y. Mitchell, Klaas Prins, Joachim Grevel, Carol A. E. Peña, Gerold Meinhardt. HATT: a phase IV, single-arm, open-label study of sorafenib in Taiwanese patients with advanced hepatocellular carcinoma. Hepatology International11(2):199-208. 2017 Mar. (SCI)
• Chi-Tan Hu, Jia-Ru Wu, Chuan-Chu Cheng, Wen-Sheng Wu*. The Therapeutic Targeting of HGF/c-Met Signaling in Hepatocellular Carcinoma: Alternative Approaches. Cancers9(6):58. 2017 Jun. (SCI)
• Yu-Hsi Hsieh*, Chih-Wei Tseng, Chi-Tan Hu, Malcolm Koo, Felix W. Leung. Prospective multicenter randomized controlled trial comparing adenoma detection rate in colonoscopy using water exchange, water immersion, and air insufflation. Gastrointestinal Endoscopy86(1):192-201. 2017 Jul. (SCI)
• Chi-Tan Hu*, Wei-Yi Lei, Jen-Shung Lin, Jui-Sheng Hung. Endoscopic meatus scoring scale versus sniff test to predict insertability before transnasal endoscopy: A prospective, randomized study. Journal of Gastroenterology and Hepatology32(12):1914-1921. 2017 Dec. (SCI)
• Wen-Sheng Wu, Ren-In You, Chuan-Chu Cheng, Ming-Che Lee, Teng-Yi Lin, Chi-Tan Hu*. Snail collaborates with EGR-1 and SP-1 to directly activate transcription of MMP 9 and ZEB1. Scientific Reports7(1):17753. 2017 Dec. (SCI)
• Jeremy Wang, Surbhi Jain, Dion Chen, Wei Song, Chi-Tan Hu*, Ying-Hsiu Su*. Development and Evaluation of Novel Statistical Methods in Urine Biomarker-Based Hepatocellular Carcinoma Screening. Scientific Reports 8(1):3799. 2018 Feb. (SCI)
• Surbhi Jain, Ying-Hsiu Su, Yih-Ping Su, Sierra McCloud, Ruixia Xue, Tai-Jung Lee, Shu-Chuan Lin, Selena Y. Lin, Wei Song, Jamin D. Steffen, Chi-Tan Hu*. Characterization of the hepatitis B virus DNA detected in urine of chronic hepatitis B patients. BMC Gastroenterology 18(1):40. 2018 Mar. (SCI)
• Ren-In You, Wen-Sheng Wu, Chuan-Chu Cheng, Jia-Ru Wu, Siou-Mei Pan, Chi-Wen Chen, Chi-Tan Hu*. Involvement of N-glycan in Multiple Receptor Tyrosine Kinases Targeted by Ling-Zhi-8 for Suppressing HCC413 Tumor Progression. Cancers11(1):9. 2018 Dec. (SCI)
• Felix W. Leung*, Malcolm Koo, Sergio Cadoni, Premysl Falt, Yu-Hsi Hsieh, Arnaldo Amato, Matteo Erriu, Petr Fojtik, Paolo Gallittu, Chi-Tan Hu, Joseph W. Leung, Mauro Liggi, Silvia Paggi, Franco Radaelli, Emanuele Rondonotti, Vit Smajstrla, Chih-Wei Tseng, Ondrej Urban. Water Exchange Produces Significantly Higher Adenoma Detection Rate Than Water Immersion: Pooled Data From 2 Multisite Randomized Controlled Trials. Journal of Clinical Gastroenterology53(3):204-209. 2019 Mar. (SCI)
• Hui Jia, Malcolm Koo, Yu-Hsi Hsieh, Chih-Wei Tseng, Chi-Tan Hu, Linhui Zhang, Tao Dong, Yanglin Pan, Felix W. Leung*. Factors Associated With Adenoma Detection in Propofol-sedated Patients. Journal of Clinical Gastroenterology53(7):523-529. 2019 Aug. (SCI)
• Jia-Ru Wu, Ren-In You, Chi-Tan Hu, Chuan-Chu Cheng, Rudy Rudy, Wen-Sheng Wu*. Hydrogen peroxide inducible clone-5 sustains NADPH oxidase-dependent reactive oxygen species-c-jun N-terminal kinase signaling in hepatocellular carcinoma. Oncogenesis 8(8):40. 2019 Aug. (SCI)
• Huei Long, Chi-Tan Hu, Ching-Feng Weng*. Antrodia Cinnamomea Prolongs Survival in a Patient with Small Cell Lung Cancer. Medicina55(10):640. 2019 Sep. (SCI)
• You-Yen Lin, Chi-Tan Hu^#, Der-Shan Sun, Te-Sheng Lien, Hsin-Hou Chang*. Thioacetamide-induced liver damage and thrombocytopenia is associated with induction of antiplatelet autoantibody in mice. Scientific Reports 9(1):17497. 2019 Nov. (SCI)

【榮譽】

• 87年度同時獲得英國劍橋大學分子生物學及倫敦大學King's College肝病研究中心（Institute of Liver Studies）博士班錄取。
• 93年度慈濟醫學雜誌(第十六卷)優秀論文選拔，基礎醫學組第一名。
• 94年度慈濟醫學雜誌(第十七卷)優秀論文選拔，基礎醫學組第一名。
• 98年度Young Investigator Award(YIA) Section亞太特殊研究獎(Asia Pacific Digestive Week, 27–30 Sep 2009, Taipei International Convention, Center Taipei, Taiwan, New Frontier in Digestive Medicine)
• 99年度第十三屆周大觀文教基金會全球熱愛生命獎章。
• 99年度慈濟醫院研究績效卓越獎資深人員第三名。
• 100年度第一、二期慈濟醫院微笑天使選拔第一名。
• 102年度花蓮慈濟醫院優秀研究論文評選-資深醫師組第三名。
• 103年度慈濟大學醫學系102學年度教學優良教師。
• 105年度花蓮慈濟醫院優秀研究論文評選-資深醫師組第三名。

醫師代碼：23005
專 長

‧一般肝膽腸胃內科
‧胃食道逆流症
‧功能性腸胃疾病
‧特殊檢查: 食道功能儀及24小時食道酸鹼測定

醫師代碼：23010
專長
．腹部超音波
．胃食道逆流