專長

體細胞製劑GTP製程開發

幹細胞生物學

動物細胞生物反應器

成體幹細胞體外大量化製程開發

藥物測試之細胞模型建立

ISO17025測試實驗室品質系統

學歷

國立交通大學 生物科技系 博士

國立東華大學 生物技術研究所 碩士

國立東華大學 生命科學系

經歷

佛教慈濟綜合醫院 研究部 助理研究員

佛教慈濟綜合醫院 研究部 博士後研究員

國立台灣大學 高分子科學與工程所 博士後研究員

喜躍生醫 產研處 處長 兼專案室主管

天賜爾生物科技 研發部 助理研究員

重大產業界成就

喜躍生醫公司：GTP實驗室規劃與建置

喜躍生醫公司：脂肪間質血管細胞群儲存規格建立

喜躍生醫公司：脂肪幹細胞無血清培養技術建立

花蓮慈濟醫院：間質幹細胞培養專利MtoBurst授權給台灣尖端公司

花蓮慈濟醫院：脂肪組織快速破碎專利授權給羅麗芬公司

花蓮慈濟醫院：台灣首例以細胞操作專用隔離手套箱系統取得TFDA細胞製備場所認可

專利

1. 人類間質幹細胞體外快速增生之佐劑、體外快速擴增人類間質幹細胞之方法、體外快速擴增人類間質幹細胞以獲取生長因子的方法及其用途。(已核准：台、中、日、美)已專屬授權台灣尖端公司。
2. 體外快速切碎脂肪組織以分離活細胞之方法。(已核准：台、中、美)已專屬授權羅麗芬公司。
3. 預防或治療眼疾之組成物和方法。(已核准：日，審查中：台、中、美)

著作

1. Protective effects of low-molecular-weight components of adipose stem cell-derived conditioned medium on dry eye syndrome in mice. Yuan-Chieh Lee, Li-Yi Sun, Jia-Rong Zhang. Sci Rep. 2021 Nov 8;11(1):21874.
2. G-CSF enhances the therapeutic potency of stem cells transplantation in spinal cord-injured rats. Cheng-Yoong Pang, Kuo-Liang Yang, Chin-Hua Fu, Li-Yi Sun, Shin-Yuan Chen, Chia-Hsin Liao. Regen Med. 2019 Jun;14(6):571-583
3. Investigating the mincing method for isolation of adipose-derived stem cells from pregnant women fat. Yuan-Sheng Li, Pao-Jen Chen, Li-Wei Wu, Pei-Wen Chou, Li-Yi Sun, Tzyy-Wen Chiou. Cytotechnology. 2018 Feb;70(1):55-66.
4. Enhancement of mitochondrial transfer by antioxidants in human mesenchymal stem cells. Chia-Jung Li, Po-Kong Chen, Li-Yi Sun, Cheng-Yoong Pang. Oxid Med Cell Longev. 2017:2017:8510805.
5. Synergistic protection of N-acetylcysteine and ascorbic acid 2-phosphate on human mesenchymal stem cells against mitoptosis, necroptosis and apoptosis. Chia-Jung Li, Li-Yi Sun, Cheng-Yoong Pang. Sci Rep. 2015 Apr 24:5:9819.
6. Expansion of semi-automatic processed human adipose-derived stem cells in medium supplemented with autologous serum and antioxidants. Li-Yi Sun, Dian-Kun Li, Pao-Jen Chen, Yu-Yu Joyce Ho, Jon-Son Kuo. J Stem Cell Res Ther. 2014 4:4.
7. Antioxidants cause rapid expansion of human adipose-derived mesenchymal stem cells via CDK and CDK inhibitor regulation. Li-Yi Sun, Cheng-Yoong Pang, Dian-Kun Li, Chia-Hsin Liao, Wei-Chao Huang, Chao-Chuan Wu, Yi-Yo Chou, Wei Wu Li, Shin-Yuan Chen, Hwan-Wun Liu, Yao-Jen Chang, Ching-Feng Cheng. J Biomed Sci. 2013 Aug 1;20(1):53.
8. Cells and materials for liver tissue engineering. Yuan-Sheng Li, Horng-Jyh Harn, Dean-Kuo Hsieh, Tung-Chou Wen, Yi-Maun Subeq, Li-Yi Sun, Shinn-Zong Lin, Tzyy-Wen Chiou. Cell Transplant. 2013;22(4):685-700.
9. Butylidenephthalide suppresses human telomerase reverse transcriptase (TERT) in human glioblastomas. Po-Cheng Lin, Shinn-Zong Lin, Yi-Lin Chen, Jeng-Shou Chang, Li-Ing Ho, Po-Yen Liu, Li-Fu Chang, Yeu-Chern Harn, Shee-Ping Chen, Li-Yi Sun, Pi-Chun Huang, Jung-Ting Chein, Chang-Hai Tsai, Chii-Wen Chou, Horng-Jyh Harn, Tzyy-Wen Chiou. Ann Surg Oncol. 2011 Nov;18(12):3514-27.
10. Functional cells cultured on microcarriers for use in regenerative medicine research. Li-Yi Sun, Shinn-Zong Lin, Yuan-Sheng Li, Horng-Jyh Harn, Tzyy-Wen Chio. Cell Transplant. 2011;20(1):49-62.
11. Transplantation of human Wharton's Jelly-derived stem cells alleviates chemically induced liver fibrosis in rats. Shinn-Zong Lin, Yao-Jen Chang, Jen-Wea Liu, Li-Fu Chang, Li-Yi Sun, Yuan-Sheng Li, Geng-Hong Luo, Chia-Hui Liao, Pin-Hsin Chen, Tse-Min Chen, Ru-Ping Lee, Kuo-Liang Yang, Horng-Jyh Harn, Tzyy-Wen Chiou. Cell Transplant. 2010;19(11):1451-63.
12. Cell proliferation of human bone marrow mesenchymal stem cells on biodegradable microcarriers enhances in vitro differentiation potential. L-Y Sun, D-K Hsieh, W-S Syu, Y-S Li, H-T Chiu, T-W Chiou. Cell Prolif. 2010 Oct;43(5):445-56.
13. Pulsed electromagnetic fields accelerate proliferation and osteogenic gene expression in human bone marrow mesenchymal stem cells during osteogenic differentiation. Li-Yi Sun, Dean-Kuo Hsieh, Po-Cheng Lin, Hsien-Tai Chiu, Tzyy-Wen Chiou. Bioelectromagnetics. 2010 Apr;31(3):209-19.
14. Mesenchymal stem cells facilitate recovery from chemically induced liver damage and decrease liver fibrosis. Yao-Jen Chang, Jen-Wea Liu, Po-Cheng Lin, Li-Yi Sun, Chih-Wen Peng, Geng-Hong Luo, Tse-Min Chen, Ru-Ping Lee, Shinn-Zong Lin, Horng-Jyh Harn, Tzyy-Wen Chiou. Life Sci. 2009 Sep 23;85(13-14):517-25.
15. Effect of pulsed electromagnetic field on the proliferation and differentiation potential of human bone marrow mesenchymal stem cells. Li-Yi Sun, Dean-Kuo Hsieh, Tzai-Chiu Yu, Hsien-Tai Chiu, Sheng-Fen Lu, Geng-Hong Luo, Tom K Kuo, Oscar K Lee, Tzyy-Wen Chiou. Bioelectromagnetics. 2009 May;30(4):251-60.
16. Pulsed electromagnetic fields accelerate proliferation and osteogenic gene expression in human bone marrow mesenchymal stem cells during osteogenic differentiation. Li-Yi Sun, Dean-Kuo Hsieh, Po-Cheng Lin, Hsien-Tai Chiu, Tzyy-Wen Chiou. Bioelectromagnetics. 2010 Apr;31(3):209-19.

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